Vitamin A Enhances Macrophages Activity Against B16-F10 Malignant Melanocytes: A New Player for Cancer Immunotherapy?

Overview

Journal Medicina (Kaunas)

Publisher MDPI

Specialty General Medicine

Date 2019 Sep 22

PMID 31540438

Citations 1

Authors

Sofia Oliveira

Jose Costa

Isabel Faria

Susana G Guerreiro

Ruben Fernandes

Affiliations

Soon will be listed here.

Abstract

: The incidence of cutaneous melanoma has been increasing. Melanoma is an aggressive form of skin cancer irresponsive to radiation and chemotherapy, rendering this cancer a disease with poor prognosis: In order to surpass some of the limitations addressed to melanoma treatment, alternatives like vitamins have been investigated. In the present study, we address this relationship and investigate the possible role of vitamin A. : We perform a co-culture assay using a macrophage cell model and RAW 264.7 from mouse, and also a murine melanoma cell line B16-F10. Macrophages were stimulated with both lipopolysaccharides (LPS) as control, and also with LPS plus vitamin A. : Using B16-F10 and RAW 264.7 cell lines, we were able to demonstrate that low concentrations of vitamin A increase cytotoxic activity of macrophages, whereas higher concentrations have the opposite effect. : These findings can constitute a new point of view related to immunostimulation by nutrients, which may be considered one major preventive strategy by enhancing the natural defense system of the body.

Citing Articles

Nutritional and antioxidant activity analyses of formulated soymilk dessert.

Hossen M, Uddin M, Khan M, Islam S, Hasanuzzaman M, Bithi U Heliyon. 2022; 8(10):e11267.

PMID: 36339995 PMC: 9634019. DOI: 10.1016/j.heliyon.2022.e11267.

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