Expert Consensus on Clinical Use of an Orally Administered Dexketoprofen Plus Tramadol Fixed-Dose Combination in Moderate-To-Severe Acute Pain: A Delphi Study

Overview

Journal Adv Ther

Date 2019 Sep 20

PMID 31535328

Citations 9

Authors

Giustino Varrassi

Stefano Coaccioli

Jose De-Andres

Magdi Hanna

Giorgos Macheras

Antonio Montero

Serge Perrot

Vincenzo Piras

Carmelo Scarpignato

Affiliations

Soon will be listed here.

Abstract

Introduction: In 2016, the orally administered fixed-dose combination of dexketoprofen 25 mg and tramadol 75 mg (DKP/TRAM FDC) was approved in Europe for short-term treatment of moderate-to-severe acute pain, an indication that encompasses a wide range of post-operative and non-surgical painful conditions. This has suggested the necessity to have a clearer indication on its clinical use, with the support of expert pain clinicians, working in different medical specialities, and reinforced by the data present in the literature.

Methods: With the aim of assisting clinicians in the use of DKP/TRAM FDC in daily practice, two rounds of a modified Delphi process were conducted. In the first round, a board of nine experts developed a series of consensus statements based on available evidence, and their clinical experience, with DKP/TRAM FDC. In the second round, 75 clinicians with extensive experience in pain management expressed individually their agreement with the statements, using a dedicated online platform. Consensus was defined as at least 70% agreement.

Results: Twenty-eight statements were developed. Of these, 19 reached the defined level of consensus.

Conclusion: The agreed consensus statements may assist clinicians in applying the results of clinical studies and clinical experience to routine care settings, providing guidance for use of this new analgesic combination in moderate-to-severe post-operative and non-surgical acute pain.

Funding: Menarini Group.

Citing Articles

Advances in the Management of Acute Postsurgical Pain: A Review.

Paladini A, Rawal N, Coca Martinez M, Trifa M, Montero A, Pergolizzi Jr J Cureus. 2023; 15(8):e42974.

PMID: 37671225 PMC: 10475855. DOI: 10.7759/cureus.42974.

Real-World Evidence on the Efficacy and Tolerability of Tramadol/Dexketoprofen (TRAM/DKP) Fixed-Dose Combination for the Management of Acute Non-surgical Pain in Asian Patients: A Multicentre Retrospective Case Series.

Tantavisut S, Ho K, Arandia E, Cheng S, Eiamtanasate S, Jarayabhand R Cureus. 2023; 15(6):e41156.

PMID: 37525772 PMC: 10386910. DOI: 10.7759/cureus.41156.

Management of Acute Cancer Pain in Asia: An Expert Opinion on the Role of Tramadol/Dexketoprofen Fixed-Dose Combination.

Tuan J, Wang E, De Leon J, Mendoza M, Varrassi G Cureus. 2023; 15(3):e35770.

PMID: 37025730 PMC: 10072166. DOI: 10.7759/cureus.35770.

Critical Appraisal of Current Acute LBP Management and the Role of a Multimodal Analgesia: A Narrative Review.

Hanna M, Perrot S, Varrassi G Pain Ther. 2023; 12(2):377-398.

PMID: 36765012 PMC: 10036717. DOI: 10.1007/s40122-023-00479-0.

DANTE Study: The First Randomized, Double-Blind, Placebo and Active-Controlled, Parallel Arm Group Study Evaluating the Analgesic Efficacy and Safety of Dexketoprofen TrometAmol aNd Tramadol Hydrochloride Oral FixEd Dose Combination on Moderate to....

Varrassi G, Hanna M, Coaccioli S, Suada M, Perrot S Pain Ther. 2022; 11(3):1055-1070.

PMID: 35788976 PMC: 9314501. DOI: 10.1007/s40122-022-00407-8.

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