NHR-14 Loss of Function Couples Intestinal Iron Uptake with Innate Immunity in Through PQM-1 Signaling

Overview

Journal Elife

Specialty Biology

Date 2019 Sep 19

PMID 31532389

Citations 22

Authors

Malini Rajan

Cole P Anderson

Paul M Rindler

Steven Joshua Romney

Maria C Ferreira Dos Santos

Jason Gertz

Elizabeth A Leibold

Affiliations

Soon will be listed here.

Abstract

Iron is essential for survival of most organisms. All organisms have thus developed mechanisms to sense, acquire and sequester iron. In s, iron uptake and sequestration are regulated by HIF-1. We previously showed that mutants are developmentally delayed when grown under iron limitation. Here we identify , encoding a nuclear receptor, in a screen conducted for mutations that rescue the developmental delay of mutants under iron limitation. loss upregulates the intestinal metal transporter SMF-3 to increase iron uptake in mutants. mutants display increased expression of innate immune genes and DAF-16/FoxO-Class II genes, and enhanced resistance to . These responses are dependent on the transcription factor PQM-1, which localizes to intestinal cell nuclei in mutants. Our data reveal how utilizes nuclear receptors to regulate innate immunity and iron availability, and show iron sequestration as a component of the innate immune response.

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