Analysis of Gut Microbiome, Nutrition and Immune Status in Autism Spectrum Disorder: a Case-control Study in Ecuador

Overview

Journal Gut Microbes

Specialties Gastroenterology
Microbiology

Date 2019 Sep 19

PMID 31530087

Citations 28

Authors

Maria Fernanda Zurita

Paul A Cardenas

Maria Elena Sandoval

Maria Caridad Pena

Marco Fornasini

Nancy Flores

Marcia H Monaco

Kirsten Berding

Sharon M Donovan

Thomas Kuntz

Jack A Gilbert

Manuel E Baldeon

Affiliations

Soon will be listed here.

Abstract

Most studies on autism spectrum disorder (ASD) risk factors have been conducted in developed countries where ethnicity and environment are different than in developing countries. We compared nutritional status, immune response and microbiota composition in mestizo children with ASD with matched controls in Ecuador. Twenty-five cases and 35 controls were matched by age, sex and school location. The prevalence of under- and overweight was higher in children with ASD. Nutritional differences were accompanied by abnormal food habits and more frequent gastrointestinal symptoms in children with ASD. Also, greater serum concentrations of TGF-β1 were observed in children with ASD. Finally, there was greater alpha diversity and abundance of (2 OTUs), and different species of in ASD children.

Citing Articles

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