White Matter Abnormalities of Corpus Callosum in Patients with Bipolar Disorder and Suicidal Ideation

Overview

Journal Ann Gen Psychiatry

Publisher Biomed Central

Specialty Psychiatry

Date 2019 Sep 19

PMID 31528196

Citations 9

Authors

Ran Zhang

Xiaowei Jiang

Miao Chang

Shengnan Wei

Yanqing Tang

Fei Wang

Affiliations

Soon will be listed here.

Abstract

Objective: Although many studies have shown that the corpus callosum (CC) may play an important role in bipolar disorder (BD) and suicide, the pathophysiological mechanism of BD underlying suicidal behavior is still unclear. This study aimed to explore the relationship between the CC, and BD and suicidal ideation using diffusion tensor imaging (DTI).

Method: A total of 203 participants (47 BD patients with suicidal ideation, 59 with BD without suicidal ideation, and 97 healthy controls [HC]) underwent DTI scanning at a single site. We examined the white matter integrity of the CC in the three groups.

Results: A comparison among groups showed that BD patients with suicidal ideation had significant lower fractional anisotropy (FA) values than those of BD without suicidal ideation and HCs in the body and genu of the CC, and FA values of BD without suicidal ideation were significantly lower than those of HCs. However, in the splenium of corpus callosum, no difference was found between BD without suicidal ideation and HCs.

Conclusions: Our findings add to the evidence suggesting that the CC plays a key role in BD with suicidal ideation, especially with respect to the role of the genu and body of the CC subserving emotion regulation.

Citing Articles

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