Deep Perifoveal Vessel Density As an Indicator of Capillary Loss in High Myopia

Overview

Journal Eye (Lond)

Specialty Ophthalmology

Date 2019 Sep 19

PMID 31527763

Citations 18

Authors

Dan Cheng

Qi Chen

Yufei Wu

Xueting Yu

Meixiao Shen

Xiran Zhuang

Zhongxu Tian

Ye Yang

Jianhua Wang

Fan Lu

Lijun Shen

Affiliations

Soon will be listed here.

Abstract

Objectives: This study investigates the macular vasculature of both vascular layers in different degrees of myopia by optical coherence tomography angiography (OCTA).

Methods: One hundred and forty-five eyes of 145 healthy subjects with spherical equivalents (SE) ranging from +0.50 to -16.50 dioptres were divided into three groups. The foveal avascular zone (FAZ) area and vessel density (VD) of OCTA images were compared.

Results: Compared with other groups, high myopia had a larger FAZ and less perifoveal VD in both layers and less deep total VD. Compared with other myopia, high myopia had less total VD in the superficial layer and parafoveal VD in the deep layer. Between emmetropia and low myopia, there was a difference only in the deep parafoveal VD. Except for the parafoveal VD in both layers and the superficial total VD, there were significant correlations of the FAZ with axial length (AL) and SE as well as VD. The deep perifoveal VD was most associated with high myopia.

Conclusions: An increased FAZ and decreased VD in both layers were correlated with AL elongation. The decreasing deep perifoveal VD was most associated with high myopia. OCTA may provide additional information regarding the progression of pathologies in high myopia.

Citing Articles

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Morphological characteristics of the foveal avascular zone in pathological myopia and its relationship with macular structure and microcirculation.

Sui J, Li H, Bai Y, He Q, Sun Z, Wei R Graefes Arch Clin Exp Ophthalmol. 2024; 262(7):2121-2133.

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Optical coherence tomography angiography of the macula of high myopia in children and adolescents.

Abdellah M, Amer A, Eldaly Z, Anber M Int J Retina Vitreous. 2024; 10(1):17.

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Retinal Artery Angles in High Axial Myopia and Its Relationship With Visual Function.

Liang J, Xie T, Chen L, Huang C, Wei P, Li P Transl Vis Sci Technol. 2023; 12(8):22.

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Age exacerbates the effect of myopia on retinal capillaries and string vessels.

Lin C, Toychiev A, Ablordeppey R, Srinivas M, Benavente-Perez A Front Med (Lausanne). 2023; 10:1112396.

PMID: 37601788 PMC: 10438986. DOI: 10.3389/fmed.2023.1112396.

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