Primary Osteosarcoma of the Skull in Teenager

Overview

Journal BMJ Case Rep

Specialty General Medicine

Date 2019 Sep 19

PMID 31527199

Citations 3

Authors

Liliana Vasquez

Victor Tejada

Ivan Maza

Ronald Mendoza

Affiliations

Soon will be listed here.

Abstract

Osteosarcoma of the skull is a rare primary malignant bone tumour in children, representing 1-2% of all cranial tumours. We describe a case of a 17-year-old adolescent with chondroblastic osteosarcoma of the parietal-occipital bone and no distant metastases at presentation treated with neoadjuvant chemotherapy, surgery and, later, concurrent chemoradiotherapy. The patient suffered progressive disease and died 15 months after diagnosis. There are at least 15 paediatric cases of osteosarcoma of the skull described in the literature. Due to its rarity, there are no broad prospective studies on this entity, which has distinctive features when compared to other craniofacial tumours, carrying a worse prognosis. Complete surgical resection is needed for long-term survival, whereas chemotherapy and radiotherapy have still questionable indications.

Citing Articles

A case of primary osteosarcoma in the occipital bone: A relatively common tumor in an uncommon location.

Xing K, Ren G, Liu S, Zhang C Acta Radiol Open. 2024; 13(9):20584601241279134.

PMID: 39224614 PMC: 11366106. DOI: 10.1177/20584601241279134.

Pediatric focal calvarial lesions: an illustrated review.

McDermott T, Amarneh M, Sato Y, Watal P, Charmi V, Fuortes M Pediatr Radiol. 2023; 53(13):2699-2711.

PMID: 37964037 DOI: 10.1007/s00247-023-05795-3.

Unusual presentation of aneurysmal bone cyst (ABC) in children: pediatric intracranial osteosarcoma with secondary ABC.

Sawant N, Gupta D, Kumar V, Biradar H, Garg A, Sharma M Childs Nerv Syst. 2023; 40(3):919-924.

PMID: 37930424 DOI: 10.1007/s00381-023-06197-4.

References

Martin E, Senders J, Ter Wengel P, Smith T, Broekman M . Treatment and survival of osteosarcoma and Ewing sarcoma of the skull: a SEER database analysis. Acta Neurochir (Wien). 2018; 161(2):317-325. PMC: 6373276. DOI: 10.1007/s00701-018-3754-y. View

Kirby E, Zhou H, Morales Jr L . Primary pediatric osteosarcoma of the skull. J Craniofac Surg. 2011; 22(6):2399-405. DOI: 10.1097/SCS.0b013e318231fe9b. View

Sturgis E, Potter B . Sarcomas of the head and neck region. Curr Opin Oncol. 2003; 15(3):239-52. DOI: 10.1097/00001622-200305000-00011. View

Gadwal S, Gannon F, Fanburg-Smith J, Becoskie E, Thompson L . Primary osteosarcoma of the head and neck in pediatric patients: a clinicopathologic study of 22 cases with a review of the literature. Cancer. 2001; 91(3):598-605. View

Nora F, Unni K, Pritchard D, Dahlin D . Osteosarcoma of extragnathic craniofacial bones. Mayo Clin Proc. 1983; 58(4):268-72. View

Lee Y, Van Tassel P, Nauert C, Raymond A, EDEIKEN J . Craniofacial osteosarcomas: plain film, CT, and MR findings in 46 cases. AJR Am J Roentgenol. 1988; 150(6):1397-402. DOI: 10.2214/ajr.150.6.1397. View

Ha P, Eisele D, Frassica F, Zahurak M, McCarthy E . Osteosarcoma of the head and neck: a review of the Johns Hopkins experience. Laryngoscope. 1999; 109(6):964-9. DOI: 10.1097/00005537-199906000-00023. View

Salvati M, Ciappetta P, Raco A . Osteosarcomas of the skull. Clinical remarks on 19 cases. Cancer. 1993; 71(7):2210-6. DOI: 10.1002/1097-0142(19930401)71:7<2210::aid-cncr2820710708>3.0.co;2-w. View

Patel S, Meyers P, Huvos A, Wolden S, Singh B, Shaha A . Improved outcomes in patients with osteogenic sarcoma of the head and neck. Cancer. 2002; 95(7):1495-503. DOI: 10.1002/cncr.10849. View

10.

Goodman M, McMaster J . Primary osteosarcoma of the skull. Clin Orthop Relat Res. 1976; (120):110-4. View

11.

Patel A, Rao V, Fox B, Suki D, Wildrick D, Sawaya R . Radiation-induced osteosarcomas of the calvarium and skull base. Cancer. 2011; 117(10):2120-6. DOI: 10.1002/cncr.25734. View

12.

Shinoda J, Kimura T, Funakoshi T, Iwata H, Tange K, Kasai C . Primary osteosarcoma of the skull--a case report and review of the literature. J Neurooncol. 1993; 17(1):81-8. DOI: 10.1007/BF01054277. View

13.

VENER J, Rice D, Newman A . Osteosarcoma and chondrosarcoma of the head and neck. Laryngoscope. 1984; 94(2 Pt 1):240-2. DOI: 10.1288/00005537-198402000-00020. View

14.

Bose B . Primary osteogenic sarcoma of the skull. Surg Neurol. 2002; 58(3-4):234-9; discussion 239-40. DOI: 10.1016/s0090-3019(02)00864-9. View

15.

Chou E, Chang C, Chen P, Chen Y, Yu J, Jung S . Long-term management of craniofacial osteosarcoma. J Craniofac Surg. 2009; 20(2):406-9. DOI: 10.1097/SCS.0b013e31819b9641. View

16.

van den Berg H, Merks J . Incidence and grading of cranio-facial osteosarcomas. Int J Oral Maxillofac Surg. 2013; 43(1):7-12. DOI: 10.1016/j.ijom.2013.06.017. View

17.

Luna-Ortiz K, Alonso-Calamaco M, Ortiz-Leyva R . Primary Frontoparietal Osteosarcoma. J Craniofac Surg. 2016; 28(2):e189-e191. DOI: 10.1097/SCS.0000000000003189. View

18.

Kassir R, Rassekh C, Kinsella J, Segas J, Carrau R, Hokanson J . Osteosarcoma of the head and neck: meta-analysis of nonrandomized studies. Laryngoscope. 1997; 107(1):56-61. DOI: 10.1097/00005537-199701000-00013. View

19.

Kanazawa R, Yoshida D, Takahashi H, Matsumoto K, Teramoto A . Osteosarcoma arising from the skull--case report. Neurol Med Chir (Tokyo). 2003; 43(2):88-91. DOI: 10.2176/nmc.43.88. View

20.

Chang C, Bergeron L, Liao C, Liao H, Chang C, Chen P . Craniofacial reconstruction of primary osteogenic sarcoma of the skull. J Plast Reconstr Aesthet Surg. 2009; 63(8):1265-8. DOI: 10.1016/j.bjps.2009.07.020. View