Comparison of Stool Antigen, Salivary IgG, Serum IgG, and Serum IgM As Diagnostic Markers of Infection in Children

Overview

Journal Iran J Microbiol

Publisher Tehran University of Medical Sciences

Specialty Infectious Diseases

Date 2019 Sep 17

PMID 31523403

Citations 3

Authors

Andy Darma

Bagus Samsu Tri Nugroho

Vinny Yoanna

Indah Sulistyani

Alpha Fardah Athiyyah

Reza Gunadi Ranuh

Subijanto Marto Sudarmo

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: Various non-invasive diagnostic tests are available for the detection of infection. The aim of this study was to compare the sensitivity and specificity of HpSA, salivary IgG, serum IgG, and serum IgM to those of endoscopic-biopsy as the gold standard for the diagnosis of infection.

Materials And Methods: This is a cross-sectional study performed among pediatric patients at Dr. Soetomo General Hospital (Surabaya, Indonesia). Fecal, blood, and saliva samples were collected from all subjects. The results of the HpSA, salivary IgG, serum IgG, and serum IgM tests were compared to the results of endoscopic-biopsy as the gold standard.

Results: Of the 37 study participants, infection was confirmed in 5 (13.33%) with serum IgG, 23 (63.33%) with serum IgM, 15 (40%) with HpSA, and 26 (70.97%) with salivary IgG. The salivary IgG enzyme-linked immunosorbent assay (ELISA) was the only diagnostic test with significantly different results, as compared to biopsy (p = 0.017).

Conclusion: The results of this study showed that HpSA, salivary IgG, and serum IgG and IgM were not sufficient to replace endoscopic-biopsy as the gold standard for the diagnosis of infection.

Citing Articles

Eradication Rate Using Stool Antigen Test in Vietnamese Children: A Prospective Multicenter Study.

Nguyen T, Robert A, Pham T, Vo K, Le L, Ma H JPGN Rep. 2023; 4(4):e374.

PMID: 38034459 PMC: 10684207. DOI: 10.1097/PG9.0000000000000374.

Antigenic Determinant of FlaA for Developing Serological Diagnostic Methods in Children.

Park H, Park S, Nizamutdinov D, Seo J, Park J, Jun J Pathogens. 2022; 11(12).

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Active Infection is Independently Associated with Nonalcoholic Steatohepatitis in Morbidly Obese Patients.

Doulberis M, Srivastava S, Polyzos S, Kountouras J, Papaefthymiou A, Klukowska-Rotzler J J Clin Med. 2020; 9(4).

PMID: 32235601 PMC: 7230908. DOI: 10.3390/jcm9040933.

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