Constitutional Delay of Puberty Versus Congenital Hypogonadotropic Hypogonadism: Genetics, Management and Updates

Overview

Journal Best Pract Res Clin Endocrinol Metab

Publisher Elsevier

Specialty Endocrinology

Date 2019 Sep 17

PMID 31522908

Citations 22

Authors

Taneli Raivio

Paivi J Miettinen

Affiliations

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Abstract

Delayed puberty (DP) affects approximately 2% of adolescents. In the vast majority of patients in both sexes, it is due to constitutional delay of growth and puberty (CDGP), a self-limited condition in which puberty starts later than usual but progresses normally. However, some CDGP patients may benefit from medical intervention with low-dose sex steroids or peroral aromatase inhibitor letrozole (only for boys). Other causes of DP include permanent hypogonadotropic hypogonadism, functional hypogonadotropic hypogonadism (due to chronic diseases and conditions), and gonadal failure. In this review we discuss these themes along with the latest achievements in the field of puberty research, and include a brief synopsis on the differential diagnosis and management of patients with CDGP and congenital hypogonadotropic hypogonadism.

Citing Articles

[A new way for the differential diagnosis of hypogonadotropic hypogonadism and constitutional delay of puberty in adolescent men aged 13.5-17 years].

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From biological marker to clinical application: the role of anti-Müllerian hormone for delayed puberty and idiopathic non-obstructive azoospermia in males.

Yuanyuan Z, Zeng Y, Guicheng Z, Zhao G, Zheng Y, Yi Z Endocr Connect. 2025; 14(3).

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Androgen receptor CAG repeat polymorphism might be a possible cause of familial constitutional delay of growth and puberty.

Kagizmanli G, Sevim R, Manyas H, Paketci A, Demir K, Bober E J Endocrinol Invest. 2024; .

PMID: 39570490 DOI: 10.1007/s40618-024-02502-3.

Role of Inhibin B, AMH, GnRHa Test and HCG Stimulation Test to Distinguish Isolated Hypogonadotropic Hypogonadism (IHH) from Constitutional Delay in Growth and Puberty (CDGP).

Sahoo B, Ravi Kumar P, Pattanaik S, Dash D, Patro D, Telagareddy R Indian J Endocrinol Metab. 2024; 28(2):153-159.

PMID: 38911112 PMC: 11189279. DOI: 10.4103/ijem.ijem_146_23.

A Current Perspective on Delayed Puberty and Its Management.

Abaci A, Besci O J Clin Res Pediatr Endocrinol. 2024; 16(4):379-400.

PMID: 38683021 PMC: 11629716. DOI: 10.4274/jcrpe.galenos.2024.2024-2-7.