» Articles » PMID: 31517081

Quantification of Knowledge Content of a High Impact Innovation: Recombinant DNA

Overview
Journal Heliyon
Specialty Social Sciences
Date 2019 Sep 14
PMID 31517081
Citations 1
Authors
Affiliations
Soon will be listed here.
Abstract

Quantitative analysis of knowledge content of a significant technological innovation is a novel approach to understand the scientific discovery process. Here we describe such an analysis applied to the invention of recombinant DNA technology in the early 1970's. Two focal papers are selected, i.e., Jackson et al., 1972 and Cohen et al., 1973. A knowledge framework called EApc is described to categorize knowledge types and their quantification. The focal papers, along with their reference lists, are used to determine the minimal scientific knowledge necessary for generating the notions central to each focal paper. Attempts are made to trace how each type of knowledge was generated by various research communities. The results are discussed in terms of their potential implications in measuring, evaluating, understanding and managing the scientific research process.

Citing Articles

Patterns of basic knowledge.

Tseng H iScience. 2022; 25(2):103803.

PMID: 35198869 PMC: 8851074. DOI: 10.1016/j.isci.2022.103803.

References
1.
Kim K, Li B, Winer J, Armanini M, Gillett N, PHILLIPS H . Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature. 1993; 362(6423):841-4. DOI: 10.1038/362841a0. View

2.
Meselson M, Weigle J . Chromosome brekage accompanying genetic recombination in bacteriophage. Proc Natl Acad Sci U S A. 1961; 47:857-68. PMC: 221352. DOI: 10.1073/pnas.47.6.857. View

3.
Smith H, WILCOX K . A restriction enzyme from Hemophilus influenzae. I. Purification and general properties. J Mol Biol. 1970; 51(2):379-91. DOI: 10.1016/0022-2836(70)90149-x. View

4.
Bosch G . Train PhD students to be thinkers not just specialists. Nature. 2020; 554(7692):277. DOI: 10.1038/d41586-018-01853-1. View

5.
Jackson D, Symons R, Berg P . Biochemical method for inserting new genetic information into DNA of Simian Virus 40: circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli. Proc Natl Acad Sci U S A. 1972; 69(10):2904-9. PMC: 389671. DOI: 10.1073/pnas.69.10.2904. View