Tau Pathology in Cognitively Normal Older Adults

Overview

Journal Alzheimers Dement (Amst)

Date 2019 Sep 14

PMID 31517026

Citations 37

Authors

Jacob Ziontz

Murat Bilgel

Andrea T Shafer

Abhay Moghekar

Wendy Elkins

Jessica Helphrey

Gabriela Gomez

Danielle June

Michael A McDonald

Robert F Dannals

Babak Behnam Azad

Luigi Ferrucci

Dean F Wong

Susan M Resnick

Affiliations

Soon will be listed here.

Abstract

Introduction: Tau pathology, a hallmark of Alzheimer's disease, is observed in the brains of virtually all individuals over 70 years.

Methods: Using F-AV-1451 (F-flortaucipir) positron emission tomography, we evaluated tau pathology in 54 cognitively normal participants (mean age: 77.5 years, SD: 8.9) from the Baltimore Longitudinal Study of Aging. We assessed associations between positron emission tomography signal and age, sex, race, and amyloid positivity. We investigated relationships between regional signal and retrospective rates of change in regional volumes and cognitive function adjusting for age, sex, and amyloid status.

Results: Greater age, male sex, black race, and amyloid positivity were associated with higher F-AV-1451 retention in distinct brain regions. Retention in the entorhinal cortex was associated with lower entorhinal volume ( = -1.124, SE = 0.485, = .025) and a steeper decline in memory performance ( = -0.086, SE = 0.039, = .029).

Discussion: Assessment of medial temporal tau pathology will provide insights into early structural brain changes associated with later cognitive impairment and Alzheimer's disease.

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