Magnitude of Nonalcoholic Fatty Liver Disease: Eastern Perspective

Overview

Journal J Clin Exp Hepatol

Publisher Elsevier

Specialty Gastroenterology

Date 2019 Sep 14

PMID 31516265

Citations 8

Authors

Becky Ching-Yeung Yu

Deborah Kwok

Vincent Wai-Sun Wong

Affiliations

Soon will be listed here.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide, affecting a quarter of the global adult population. Nonalcoholic steatohepatitis, the more active form of NAFLD with active hepatic necroinflammation and faster fibrosis progression, has become one of the leading indications for liver transplantation and an important cause of hepatocellular carcinoma in Western countries. Epidemiological studies suggest that NAFLD is almost equally prevalent in Asia as in the West, but severe liver complications appear to be less common. In this article, we review the epidemiology, clinical characteristics, risk factors and clinical outcomes of NAFLD in Asia. We highlight the issue of NAFLD in the nonobese population and discuss whether it is a unique phenomenon in Asia. Because of the rapidly changing epidemiology and natural history, future studies should continue to monitor the magnitude of NAFLD in Asia and define the best policy to control this new epidemic.

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References

Visscher T, Seidell J, Molarius A, van der Kuip D, Hofman A, Witteman J . A comparison of body mass index, waist-hip ratio and waist circumference as predictors of all-cause mortality among the elderly: the Rotterdam study. Int J Obes Relat Metab Disord. 2001; 25(11):1730-5. DOI: 10.1038/sj.ijo.0801787. View

Kojima S, Watanabe N, Numata M, Ogawa T, Matsuzaki S . Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical background. J Gastroenterol. 2003; 38(10):954-61. DOI: 10.1007/s00535-003-1178-8. View

Fan J, Zhu J, Li X, Chen L, Li L, Dai F . Prevalence of and risk factors for fatty liver in a general population of Shanghai, China. J Hepatol. 2005; 43(3):508-14. DOI: 10.1016/j.jhep.2005.02.042. View

Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio L . Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 2008; 40(12):1461-5. PMC: 2597056. DOI: 10.1038/ng.257. View

Chan J, Malik V, Jia W, Kadowaki T, Yajnik C, Yoon K . Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA. 2009; 301(20):2129-40. DOI: 10.1001/jama.2009.726. View

Das K, Das K, Mukherjee P, Ghosh A, Ghosh S, Mridha A . Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease. Hepatology. 2010; 51(5):1593-602. DOI: 10.1002/hep.23567. View

Petersen K, Dufour S, Hariri A, Nelson-Williams C, Foo J, Zhang X . Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. N Engl J Med. 2010; 362(12):1082-9. PMC: 2976042. DOI: 10.1056/NEJMoa0907295. View

Lim S, Kim J, Yoon J, Kang S, Choi S, Park Y . Sarcopenic obesity: prevalence and association with metabolic syndrome in the Korean Longitudinal Study on Health and Aging (KLoSHA). Diabetes Care. 2010; 33(7):1652-4. PMC: 2890376. DOI: 10.2337/dc10-0107. View

Wong V, Wong G, Choi P, Chan A, Li M, Chan H . Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years. Gut. 2010; 59(7):969-74. DOI: 10.1136/gut.2009.205088. View

10.

Yasui K, Hashimoto E, Komorizono Y, Koike K, Arii S, Imai Y . Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma. Clin Gastroenterol Hepatol. 2011; 9(5):428-33. DOI: 10.1016/j.cgh.2011.01.023. View

11.

Sookoian S, Pirola C . Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology. 2011; 53(6):1883-94. DOI: 10.1002/hep.24283. View

12.

Aron-Wisnewsky J, Minville C, Tordjman J, Levy P, Bouillot J, Basdevant A . Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obese. J Hepatol. 2011; 56(1):225-33. DOI: 10.1016/j.jhep.2011.04.022. View

13.

Wong V, Chu W, Wong G, Chan R, Chim A, Ong A . Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography. Gut. 2011; 61(3):409-15. DOI: 10.1136/gutjnl-2011-300342. View

14.

Kawamura Y, Arase Y, Ikeda K, Seko Y, Imai N, Hosaka T . Large-scale long-term follow-up study of Japanese patients with non-alcoholic Fatty liver disease for the onset of hepatocellular carcinoma. Am J Gastroenterol. 2011; 107(2):253-61. DOI: 10.1038/ajg.2011.327. View

15.

Matthews C, George S, Moore S, Bowles H, Blair A, Park Y . Amount of time spent in sedentary behaviors and cause-specific mortality in US adults. Am J Clin Nutr. 2012; 95(2):437-45. PMC: 3260070. DOI: 10.3945/ajcn.111.019620. View

16.

Kwon Y, Oh S, Hwang S, Lee C, Kwon H, Chung G . Association of nonalcoholic fatty liver disease with components of metabolic syndrome according to body mass index in Korean adults. Am J Gastroenterol. 2012; 107(12):1852-8. DOI: 10.1038/ajg.2012.314. View

17.

Kitamoto T, Kitamoto A, Yoneda M, Hyogo H, Ochi H, Nakamura T . Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan. Hum Genet. 2013; 132(7):783-92. DOI: 10.1007/s00439-013-1294-3. View

18.

Wong V, Chan R, Wong G, Cheung B, Chu W, Yeung D . Community-based lifestyle modification programme for non-alcoholic fatty liver disease: a randomized controlled trial. J Hepatol. 2013; 59(3):536-42. DOI: 10.1016/j.jhep.2013.04.013. View

19.

Hong H, Hwang S, Choi H, Yoo H, Seo J, Kim S . Relationship between sarcopenia and nonalcoholic fatty liver disease: the Korean Sarcopenic Obesity Study. Hepatology. 2013; 59(5):1772-8. DOI: 10.1002/hep.26716. View

20.

Li Z, Xue J, Chen P, Chen L, Yan S, Liu L . Prevalence of nonalcoholic fatty liver disease in mainland of China: a meta-analysis of published studies. J Gastroenterol Hepatol. 2013; 29(1):42-51. DOI: 10.1111/jgh.12428. View