INNATE IMMUNITY IN NEPHROTOXIC ACUTE KIDNEY INJURY

Overview

Journal Trans Am Clin Climatol Assoc

Specialty Rehabilitation Medicine

Date 2019 Sep 14

PMID 31516162

Citations 5

Authors

W Brian Reeves

Affiliations

Soon will be listed here.

Abstract

Acute kidney injury (AKI) is common among hospitalized patients and is associated with high morbidity and mortality. Inflammation is recognized to play an important role in both ischemic and toxic models of AKI. Cisplatin is a widely used and highly effective cancer chemotherapeutic agent but carries the risk of nephrotoxicity. We have used a model of cisplatin-induced AKI to explore the functions of the innate immune response in kidney injury. Several components of innate immunity, such as Toll-like receptor sensing and inflammatory cytokine production, contribute to both ischemic and cisplatin-induced AKI. Importantly, it is the activity of these components in kidney parenchymal cells, rather than immune cells, which mediate AKI. Cellular components of innate immunity, such as neutrophils and dendritic cells, appear to play disparate roles in ischemic vs toxic AKI. Innate immune pathways could be targeted to prevent or treat AKI.

Citing Articles

Role of the CDKL1-SOX11 signaling axis in acute kidney injury.

Silvaroli J, Martinez G, Vanichapol T, Davidson A, Zepeda-Orozco D, Pabla N Am J Physiol Renal Physiol. 2024; 327(3):F426-F434.

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Empagliflozin protective effects against cisplatin-induced acute nephrotoxicity by interfering with oxidative stress and inflammation in Wistar rats.

Farrokh-Eslamlou N, Momtaz S, Niknejad A, Hosseini Y, Mahdaviani P, Ghasemnejad-Berenji M Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(9):7061-7070.

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Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury.

Kim J, Silvaroli J, Vasquez Martinez G, Bisunke B, Luna Ramirez A, Jayne L Kidney Int. 2023; 103(6):1093-1104.

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Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological Mechanisms, Pharmacological Interventions, and Genetic Mitigations.

McSweeney K, Kate Gadanec L, Qaradakhi T, Ali B, Zulli A, Apostolopoulos V Cancers (Basel). 2021; 13(7).

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Ameliorative Effect of Linalool in Cisplatin-Induced Nephrotoxicity: The Role of HMGB1/TLR4/NF-κB and Nrf2/HO1 Pathways.

Mohamed M, Abduldaium Y, Younis N Biomolecules. 2020; 10(11).

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