Effects of High Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS) on Delay Discounting in Major Depressive Disorder: An Open-Label Uncontrolled Pilot Study

Overview

Journal Brain Sci

Publisher MDPI

Date 2019 Sep 14

PMID 31514324

Citations 3

Authors

Juliana Teti Mayer

Magali Nicolier

Gregory Tio

Stephane Mouchabac

Emmanuel Haffen

Djamila Bennabi

Affiliations

Soon will be listed here.

Abstract

Background: Delay discounting (DD) refers to the decrease of a present subjective value of a future reward as the delay of its delivery increases. Major depressive disorder (MDD), besides core emotional and physical symptoms, involves difficulties in reward processing. Depressed patients often display greater temporal discounting rates than healthy subjects. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique applied in several countries to adult patients with treatment resistant depression. Studies suggest that this technique can be used to modulate DD, but no trial has assessed its effects on depressed patients.

Methods: In this open-label uncontrolled trial, 20 patients diagnosed with MDD and at least stage II treatment resistance criteria underwent 20 HF-rTMS sessions over the dorsolateral prefrontal cortex (dlPFC; 10 Hz, 110% MT, 20 min). Pre-post treatment DD rates were compared. Effects on impulsivity, personality factors, and depressive symptoms were also evaluated.

Results: No significant effect of HF-rTMS over the left dlPFC on DD of depressed individuals was observed, although rates seemed to increase after sessions. However, treatment resulted in significant improvement on cognitive impulsivity and depressive symptoms, and was well-tolerated.

Conclusion: Despite the limitations involved, this pilot study allows preliminary evaluation of HF-rTMS effects on DD in MDD, providing substrate for further research.

Citing Articles

Discounting of delayed rewards: Missing data imputation for the 21- and 27-item monetary choice questionnaires.

Yeh Y, Tegge A, Freitas-Lemos R, Myerson J, Green L, Bickel W PLoS One. 2023; 18(10):e0292258.

PMID: 37844072 PMC: 10578570. DOI: 10.1371/journal.pone.0292258.

Neural Correlates of Delay Discounting in the Light of Brain Imaging and Non-Invasive Brain Stimulation: What We Know and What Is Missed.

Moro A, Saccenti D, Ferro M, Scaini S, Malgaroli A, Lamanna J Brain Sci. 2023; 13(3).

PMID: 36979213 PMC: 10046576. DOI: 10.3390/brainsci13030403.

Impact of Repetitive Transcranial Magnetic Stimulation (rTMS) on Theory of Mind and Executive Function in Major Depressive Disorder and Its Correlation with Brain-Derived Neurotrophic Factor (BDNF): A Randomized, Double-Blind, Sham-Controlled Trial.

Tong J, Zhang J, Jin Y, Liu W, Wang H, Huang Y Brain Sci. 2021; 11(6).

PMID: 34207545 PMC: 8228992. DOI: 10.3390/brainsci11060765.

References

McClure S, Laibson D, Loewenstein G, Cohen J . Separate neural systems value immediate and delayed monetary rewards. Science. 2004; 306(5695):503-7. DOI: 10.1126/science.1100907. View

Pitcher J, Ogston K, Miles T . Age and sex differences in human motor cortex input-output characteristics. J Physiol. 2003; 546(Pt 2):605-13. PMC: 2342521. DOI: 10.1113/jphysiol.2002.029454. View

Rush A, Trivedi M, Ibrahim H, Carmody T, Arnow B, Klein D . The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression. Biol Psychiatry. 2003; 54(5):573-83. DOI: 10.1016/s0006-3223(02)01866-8. View

Ainslie G . Specious reward: a behavioral theory of impulsiveness and impulse control. Psychol Bull. 1975; 82(4):463-96. DOI: 10.1037/h0076860. View

Sheffer C, Mennemeier M, Landes R, Bickel W, Brackman S, Dornhoffer J . Neuromodulation of delay discounting, the reflection effect, and cigarette consumption. J Subst Abuse Treat. 2013; 45(2):206-14. PMC: 3690153. DOI: 10.1016/j.jsat.2013.01.012. View

Lempert K, Pizzagalli D . Delay discounting and future-directed thinking in anhedonic individuals. J Behav Ther Exp Psychiatry. 2010; 41(3):258-64. PMC: 2862767. DOI: 10.1016/j.jbtep.2010.02.003. View

Pine A, Shiner T, Seymour B, Dolan R . Dopamine, time, and impulsivity in humans. J Neurosci. 2010; 30(26):8888-96. PMC: 3059485. DOI: 10.1523/JNEUROSCI.6028-09.2010. View

Vinckier F, Gourion D, Mouchabac S . Anhedonia predicts poor psychosocial functioning: Results from a large cohort of patients treated for major depressive disorder by general practitioners. Eur Psychiatry. 2017; 44:1-8. DOI: 10.1016/j.eurpsy.2017.02.485. View

Kirby K, Petry N, Bickel W . Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls. J Exp Psychol Gen. 1999; 128(1):78-87. DOI: 10.1037//0096-3445.128.1.78. View

10.

Strafella A, Paus T, Fraraccio M, Dagher A . Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortex. Brain. 2003; 126(Pt 12):2609-15. DOI: 10.1093/brain/awg268. View

11.

Pulcu E, Trotter P, Thomas E, McFarquhar M, Juhasz G, Sahakian B . Temporal discounting in major depressive disorder. Psychol Med. 2013; 44(9):1825-34. PMC: 4035754. DOI: 10.1017/S0033291713002584. View

12.

John O . Los Cinco Grandes across cultures and ethnic groups: multitrait multimethod analyses of the Big Five in Spanish and English. J Pers Soc Psychol. 1998; 75(3):729-50. DOI: 10.1037//0022-3514.75.3.729. View

13.

Silvanto J, Pascual-Leone A . State-dependency of transcranial magnetic stimulation. Brain Topogr. 2008; 21(1):1-10. PMC: 3049188. DOI: 10.1007/s10548-008-0067-0. View

14.

Castellanos F, Tannock R . Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci. 2002; 3(8):617-28. DOI: 10.1038/nrn896. View

15.

Vanderhasselt M, Baeken C, Hendricks M, De Raedt R . The effects of high frequency rTMS on negative attentional bias are influenced by baseline state anxiety. Neuropsychologia. 2011; 49(7):1824-30. DOI: 10.1016/j.neuropsychologia.2011.03.006. View

16.

Willner P, Scheel-Kruger J, Belzung C . The neurobiology of depression and antidepressant action. Neurosci Biobehav Rev. 2012; 37(10 Pt 1):2331-71. DOI: 10.1016/j.neubiorev.2012.12.007. View

17.

Swann A, Bjork J, Moeller F, Dougherty D . Two models of impulsivity: relationship to personality traits and psychopathology. Biol Psychiatry. 2002; 51(12):988-94. DOI: 10.1016/s0006-3223(01)01357-9. View

18.

Pripfl J, Neumann R, Kohler U, Lamm C . Effects of transcranial direct current stimulation on risky decision making are mediated by 'hot' and 'cold' decisions, personality, and hemisphere. Eur J Neurosci. 2013; 38(12):3778-85. DOI: 10.1111/ejn.12375. View

19.

Williams L . Precision psychiatry: a neural circuit taxonomy for depression and anxiety. Lancet Psychiatry. 2016; 3(5):472-80. PMC: 4922884. DOI: 10.1016/S2215-0366(15)00579-9. View

20.

Lefaucheur J . Methods of therapeutic cortical stimulation. Neurophysiol Clin. 2009; 39(1):1-14. DOI: 10.1016/j.neucli.2008.11.001. View