ZIKAVID-Zika Virus Infection Database: a New Platform to Analyze the Molecular Impact of Zika Virus Infection

Overview

Journal J Neurovirol

Publisher Springer

Specialties Microbiology
Neurology

Date 2019 Sep 13

PMID 31512145

Citations 3

Authors

Rafael L Rosa

Lucelia Santi

Markus Berger

Emanuela F Tureta

Andre Quincozes-Santos

Diogo O Souza

Jorge A Guimaraes

Walter O Beys-da-Silva

Affiliations

Soon will be listed here.

Abstract

The recent outbreak of Zika virus (ZIKV) in Brazil and other countries globally demonstrated the relevance of ZIKV studies. During and after this outbreak, there was an intense increase in scientific production on ZIKV infections, especially toward alterations promoted by the infection and related to clinical outcomes. Considering this massive amount of new data, mainly thousands of genes and proteins whose expression is impacted by ZIKV infection, the ZIKA Virus Infection Database (ZIKAVID) was created. ZIKAVID is an online database that comprises all genes or proteins, and associated information, for which expression was experimentally measured and found to be altered after ZIKV infection. The database, available at https://zikavid.org, contains 16,984 entries of gene expression measurements from a total of 7348 genes. It allows users to easily perform searches for different experimental hosts (cell lines, tissues, and animal models), ZIKV strains (African, Asian, and Brazilian), and target molecules (messenger RNA [mRNA] and protein), among others, used in differential expression studies regarding ZIKV infection. In this way, the ZIKAVID will serve as an additional and important resource to improve the characterization of the molecular impact and pathogenesis associated with ZIKV infection.

Citing Articles

Insight into the Natural Biomolecules (BMs): Promising Candidates as Zika Virus Inhibitors.

Dobhal K, Garg R, Singh A, Semwal A Infect Disord Drug Targets. 2024; 24(7):e020224226681.

PMID: 38318833 DOI: 10.2174/0118715265272414231226092146.

Neurodevelopment in Children Exposed to Zika : Clinical and Molecular Aspects.

Schuler-Faccini L, Del Campo M, Garcia-Alix A, Ventura L, Boquett J, Van der Linden V Front Genet. 2022; 13:758715.

PMID: 35350244 PMC: 8957982. DOI: 10.3389/fgene.2022.758715.

SARSCOVIDB-A New Platform for the Analysis of the Molecular Impact of SARS-CoV-2 Viral Infection.

da Rosa R, Yang T, Tureta E, de Oliveira L, Moraes A, Tatara J ACS Omega. 2021; 6(4):3238-3243.

PMID: 33553941 PMC: 7839156. DOI: 10.1021/acsomega.0c05701.

References

Grant A, Ponia S, Tripathi S, Balasubramaniam V, Miorin L, Sourisseau M . Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling. Cell Host Microbe. 2016; 19(6):882-90. PMC: 4900918. DOI: 10.1016/j.chom.2016.05.009. View

Hu T, Li J, Carr M, Duchene S, Shi W . The Asian Lineage of Zika Virus: Transmission and Evolution in Asia and the Americas. Virol Sin. 2019; 34(1):1-8. PMC: 6420435. DOI: 10.1007/s12250-018-0078-2. View

Mishra A, Vijayakumar P, Raut A . Emerging avian influenza infections: Current understanding of innate immune response and molecular pathogenesis. Int Rev Immunol. 2017; 36(2):89-107. DOI: 10.1080/08830185.2017.1291640. View

Tabata T, Petitt M, Puerta-Guardo H, Michlmayr D, Wang C, Fang-Hoover J . Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission. Cell Host Microbe. 2016; 20(2):155-66. PMC: 5257282. DOI: 10.1016/j.chom.2016.07.002. View

Beys-da-Silva W, Rosa R, Santi L, Berger M, Park S, Campos A . Zika Virus Infection of Human Mesenchymal Stem Cells Promotes Differential Expression of Proteins Linked to Several Neurological Diseases. Mol Neurobiol. 2018; 56(7):4708-4717. PMC: 6491274. DOI: 10.1007/s12035-018-1417-x. View

Hulo C, de Castro E, Masson P, Bougueleret L, Bairoch A, Xenarios I . ViralZone: a knowledge resource to understand virus diversity. Nucleic Acids Res. 2010; 39(Database issue):D576-82. PMC: 3013774. DOI: 10.1093/nar/gkq901. View

Schuler-Faccini L, Roehe P, Zimmer E, Quincozes-Santos A, de Assis A, Cirne Lima E . ZIKA Virus and Neuroscience: the Need for a Translational Collaboration. Mol Neurobiol. 2017; 55(2):1551-1555. DOI: 10.1007/s12035-017-0429-2. View

Calvet G, Aguiar R, Melo A, Sampaio S, de Filippis I, Fabri A . Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis. 2016; 16(6):653-660. DOI: 10.1016/S1473-3099(16)00095-5. View

Mitchell Iii R, Wallace A, Hodgson E, Roe R . Differential Expression Profile of lncRNAs from Primary Human Hepatocytes Following DEET and Fipronil Exposure. Int J Mol Sci. 2017; 18(10). PMC: 5666786. DOI: 10.3390/ijms18102104. View

10.

Pickett B, Sadat E, Zhang Y, Noronha J, Squires R, Hunt V . ViPR: an open bioinformatics database and analysis resource for virology research. Nucleic Acids Res. 2011; 40(Database issue):D593-8. PMC: 3245011. DOI: 10.1093/nar/gkr859. View

11.

Yun S, Song B, Frank J, Julander J, Olsen A, Polejaeva I . Functional Genomics and Immunologic Tools: The Impact of Viral and Host Genetic Variations on the Outcome of Zika Virus Infection. Viruses. 2018; 10(8). PMC: 6116225. DOI: 10.3390/v10080422. View

12.

Mlakar J, Korva M, Tul N, Popovic M, Poljsak-Prijatelj M, Mraz J . Zika Virus Associated with Microcephaly. N Engl J Med. 2016; 374(10):951-8. DOI: 10.1056/NEJMoa1600651. View

13.

DICK G, KITCHEN S, HADDOW A . Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg. 1952; 46(5):509-20. DOI: 10.1016/0035-9203(52)90042-4. View

14.

Duffy M, Chen T, Hancock W, Powers A, Kool J, Lanciotti R . Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009; 360(24):2536-43. DOI: 10.1056/NEJMoa0805715. View

15.

Lindqvist R, Mundt F, Gilthorpe J, Wolfel S, Gekara N, Kroger A . Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects. J Neuroinflammation. 2016; 13(1):277. PMC: 5078952. DOI: 10.1186/s12974-016-0748-7. View

16.

Beaver J, Lelutiu N, Habib R, Skountzou I . Evolution of Two Major Zika Virus Lineages: Implications for Pathology, Immune Response, and Vaccine Development. Front Immunol. 2018; 9:1640. PMC: 6058022. DOI: 10.3389/fimmu.2018.01640. View

17.

Papanikolaou N, Pavlopoulos G, Theodosiou T, Iliopoulos I . Protein-protein interaction predictions using text mining methods. Methods. 2014; 74:47-53. DOI: 10.1016/j.ymeth.2014.10.026. View

18.

Guirimand T, Delmotte S, Navratil V . VirHostNet 2.0: surfing on the web of virus/host molecular interactions data. Nucleic Acids Res. 2014; 43(Database issue):D583-7. PMC: 4383936. DOI: 10.1093/nar/gku1121. View

19.

Dowall S, Graham V, Rayner E, Hunter L, Atkinson B, Pearson G . Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) mice. PLoS Negl Trop Dis. 2017; 11(7):e0005704. PMC: 5510909. DOI: 10.1371/journal.pntd.0005704. View

20.

Jiang X, Dong X, Li S, Zhou Y, Rayner S, Xia H . Proteomic Analysis of Zika Virus Infected Primary Human Fetal Neural Progenitors Suggests a Role for Doublecortin in the Pathological Consequences of Infection in the Cortex. Front Microbiol. 2018; 9:1067. PMC: 5996093. DOI: 10.3389/fmicb.2018.01067. View