Cytological Grading of Breast Tumors-The Human and Canine Perspective

Overview

Journal Front Vet Sci

Specialty Veterinary Medicine

Date 2019 Sep 12

PMID 31508437

Citations 5

Authors

Krithiga Kuppusamy

Aarathi Rajan

Aarathy Warrier

Revathy Nadhan

Dipyaman Patra

Priya Srinivas

Affiliations

Soon will be listed here.

Abstract

Human breast cancers (HBCs) are one of the leading causes of global cancer death among women. Domesticated canines are the most affected domestic species with a prevalence rate of breast cancer more than three times in women. While the human cancer patients receive substantial diagnostic and treatment facilities, inadequacy in canine cancer care, calls for greater attention. Fine Needle Aspiration Cytology (FNAC) is comparatively simple, quick, and easily reproducible technique, which aids in pre-surgical diagnosis. In humans, FNAC has a standard protocol, the Robinson's grading system, which has high correlation with the established histological grading system of Scarff Bloom- Richardson. However, Canine Mammary Tumors (CMTs), which are known to be similar to HBCs in biological behavior and gene expressions, still bank on the histopathological methods for diagnostic purposes. This review sheds light on various factors that could be considered for developing a standard FNAC technique for CMT grading and analyzes its future perspectives.

Citing Articles

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References

Taniguchi E, Yang Q, Tang W, Nakamura Y, Shan L, Nakamura M . Cytologic grading of invasive breast carcinoma. Correlation with clinicopathologic variables and predictive value of nodal metastasis. Acta Cytol. 2000; 44(4):587-91. DOI: 10.1159/000328533. View

Schiller A, Tadros T, Birdsong G, Grossl N . Cellular dyscohesion in fine-needle aspiration of breast carcinoma. Prognostic indicator for axillary lymph node metastases?. Am J Clin Pathol. 2001; 115(2):219-23. DOI: 10.1309/PR6K-7RXQ-NJUD-443Q. View

Denley H, Pinder S, Elston C, Lee A, Ellis I . Preoperative assessment of prognostic factors in breast cancer. J Clin Pathol. 2001; 54(1):20-4. PMC: 1731277. DOI: 10.1136/jcp.54.1.20. View

Eifel P, Axelson J, Costa J, Crowley J, Curran Jr W, Deshler A . National Institutes of Health Consensus Development Conference Statement: adjuvant therapy for breast cancer, November 1-3, 2000. J Natl Cancer Inst. 2001; 93(13):979-89. DOI: 10.1093/jnci/93.13.979. View

Moe L . Population-based incidence of mammary tumours in some dog breeds. J Reprod Fertil Suppl. 2002; 57:439-43. View

BLOOM H, Richardson W . Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer. 1957; 11(3):359-77. PMC: 2073885. DOI: 10.1038/bjc.1957.43. View

Khan M, Haleem A, Al Hassani H, Kfoury H . Cytopathological grading, as a predictor of histopathological grade, in ductal carcinoma (NOS) of breast, on air-dried Diff-Quik smears. Diagn Cytopathol. 2003; 29(4):185-93. DOI: 10.1002/dc.10285. View

Das A, Kapila K, Dinda A, Verma K . Comparative evaluation of grading of breast carcinomas in fine needle aspirates by two methods. Indian J Med Res. 2004; 118:247-50. View

Robles-Frias A, Gonzalez-Campora R, Martinez-Parra D, Robles-Frias M, Vazquez-Cerezuela T, Otal-Salaverri C . Robinson cytologic grading of invasive ductal breast carcinoma: correlation with histologic grading and regional lymph node metastasis. Acta Cytol. 2005; 49(2):149-53. DOI: 10.1159/000326123. View

10.

Fan F, Namiq A, Tawfik O, Thomas P . Proposed prognostic score for breast carcinoma on fine needle aspiration based on nuclear grade, cellular dyscohesion and bare atypical nuclei. Diagn Cytopathol. 2006; 34(8):542-6. DOI: 10.1002/dc.20529. View

11.

Cassali G, Gobbi H, Malm C, Schmitt F . Evaluation of accuracy of fine needle aspiration cytology for diagnosis of canine mammary tumours: comparative features with human tumours. Cytopathology. 2007; 18(3):191-6. DOI: 10.1111/j.1365-2303.2007.00412.x. View

12.

Simon D, Schoenrock D, Nolte I, Baumgartner W, Barron R, Mischke R . Cytologic examination of fine-needle aspirates from mammary gland tumors in the dog: diagnostic accuracy with comparison to histopathology and association with postoperative outcome. Vet Clin Pathol. 2009; 38(4):521-8. DOI: 10.1111/j.1939-165X.2009.00150.x. View

13.

Hunt C, Ellis I, Elston C, Locker A, Pearson D, Blamey R . Cytological grading of breast carcinoma--a feasible proposition?. Cytopathology. 1990; 1(5):287-95. DOI: 10.1111/j.1365-2303.1990.tb00362.x. View

14.

Wani F, Bhardwaj S, Kumar D, Katoch P . Cytological grading of breast cancers and comparative evaluation of two grading systems. J Cytol. 2010; 27(2):55-8. PMC: 3001176. DOI: 10.4103/0970-9371.70738. View

15.

Sontas B, Yuzbasioglu Ozturk G, Toydemir T, Arun S, Ekici H . Fine-needle aspiration biopsy of canine mammary gland tumours: a comparison between cytology and histopathology. Reprod Domest Anim. 2011; 47(1):125-30. DOI: 10.1111/j.1439-0531.2011.01810.x. View

16.

Rekha T, Nandini N, Dhar M . Validity of different cytological grading systems of breast carcinoma--a hospital-based study in South India. Asian Pac J Cancer Prev. 2012; 12(11):3013-6. View

17.

Bonzanini M, Morelli L, Bonandini E, Leonardi E, Pertile R, Dalla Palma P . Cytologic features of triple-negative breast carcinoma. Cancer Cytopathol. 2012; 120(6):401-9. DOI: 10.1002/cncy.21207. View

18.

Vasudev V, R R, V G . The cytological grading of malignant neoplasms of the breast and its correlation with the histological grading. J Clin Diagn Res. 2013; 7(6):1035-9. PMC: 3708192. DOI: 10.7860/JCDR/2013/5906.3093. View

19.

Bansal C, Pujani M, Sharma K, Srivastava A, Singh U . Grading systems in the cytological diagnosis of breast cancer: a review. J Cancer Res Ther. 2015; 10(4):839-45. DOI: 10.4103/0973-1482.140979. View

20.

Tavasoly A, Golshahi H, Rezaie A, Farhadi M . Classification and grading of canine malignant mammary tumors. Vet Res Forum. 2015; 4(1):25-30. PMC: 4293893. View