NK Cells Contribute to the Immune Risk Profile in Kidney Transplant Candidates

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2019 Sep 12

PMID 31507586

Citations 2

Authors

David DeWolfe

Malika Aid

Kevin McGann

Joshua Ghofrani

Emma Geiger

Catherine Helzer

Shaily Malik

Steve Kleiboeker

Stephanie Jost

Chen Sabrina Tan

Affiliations

Soon will be listed here.

Abstract

A previously proposed immune risk profile (IRP), based on T cell phenotype and CMV serotype, is associated with mortality in the elderly and increased infections post-kidney transplant. To evaluate if NK cells contribute to the IRP and if the IRP can be predicted by a clinical T cell functional assays, we conducted a cross sectional study in renal transplant candidates to determine the incidence of IRP and its association with specific NK cell characteristics and ImmuKnow® value. Sixty five subjects were enrolled in 5 cohorts designated by age and dialysis status. We determined T and NK cell phenotypes by flow cytometry and analyzed multiple factors contributing to IRP. We identified 14 IRP+ [CMV seropositivity and CD4/CD8 ratio < 1 or being in the highest quintile of CD8+ senescent (28CD-/CD57+) T cells] individuals equally divided amongst the cohorts. Multivariable linear regression revealed a distinct IRP+ group. Age and dialysis status did not predict immune senescence in kidney transplant candidates. NK cell features alone could discriminate IRP- and IRP+ patients, suggesting that NK cells significantly contribute to the overall immune status in kidney transplant candidates and that a combined T and NK cell phenotyping can provide a more detailed IRP definition. ImmuKnow® value was negatively correlated to age and significantly lower in IRP+ patients and predicts IRP when used alone or in combination with NK cell features. NK cells contribute to overall immune senescence in kidney transplant candidates.

Citing Articles

Association of IL-15 and IP-10 Serum Levels with Cytomegalovirus Infection, CMV Viral Load and Cyclosporine Level after Kidney Transplantation.

Asadzadeh R, Ahmadpoor P, Nafar M, Samavat S, Nikoueinejad H, Hosseinzadeh M Rep Biochem Mol Biol. 2021; 10(2):216-223.

PMID: 34604411 PMC: 8480297. DOI: 10.52547/rbmb.10.2.216.

Perirenal Adipose Tissue Displays an Age-Dependent Inflammatory Signature Associated With Early Graft Dysfunction of Marginal Kidney Transplants.

Boissier R, Francois P, Gondran Tellier B, Meunier M, Lyonnet L, Simoncini S Front Immunol. 2020; 11:445.

PMID: 32256495 PMC: 7089962. DOI: 10.3389/fimmu.2020.00445.

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