Different Approaches to Modulation of Microglia Phenotypes After Spinal Cord Injury

Overview

Journal Front Syst Neurosci

Specialty Neurology

Date 2019 Sep 12

PMID 31507384

Citations 58

Authors

Elvira Akhmetzyanova

Konstantin Kletenkov

Yana Mukhamedshina

Albert Rizvanov

Affiliations

Soon will be listed here.

Abstract

Microglial cells, which are highly plastic, immediately respond to any change in the microenvironment by becoming activated and shifting the phenotype toward neurotoxicity or neuroprotection. The polarization of microglia/macrophages after spinal cord injury (SCI) seems to be a dynamic process and can change depending on the microenvironment, stage, course, and severity of the posttraumatic process. Effective methods to modulate microglia toward a neuroprotective phenotype in order to stimulate neuroregeneration are actively sought for. In this context, available approaches that can selectively impact the polarization of microglia/macrophages regulate synthesis of trophic factors and cytokines/chemokines in them, and their phagocytic function and effects on the course and outcome of SCI are discussed in this review.

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