Antibiotics: Combatting Tolerance To Stop Resistance

Overview

Journal mBio

Publisher American Society for Microbiology

Specialty Microbiology

Date 2019 Sep 12

PMID 31506315

Citations 82

Authors

Etthel M Windels

Joran E Michiels

Bram Van den Bergh

Maarten Fauvart

Jan Michiels

Affiliations

Soon will be listed here.

Abstract

Antibiotic resistance poses an alarming and ever-increasing threat to modern health care. Although the current antibiotic crisis is widely acknowledged, actions taken so far have proved insufficient to slow down the rampant spread of resistant pathogens. Problematically, routine screening methods and strategies to restrict therapy failure almost exclusively focus on genetic resistance, while evidence for dangers posed by other bacterial survival strategies is mounting. Antibiotic tolerance, occurring either population-wide or in a subpopulation of cells, allows bacteria to transiently overcome antibiotic treatment and is overlooked in clinical practice. In addition to prolonging treatment and causing relapsing infections, recent studies have revealed that tolerance also accelerates the emergence of resistance. These critical findings emphasize the need for strategies to combat tolerance, not only to improve treatment of recurrent infections but also to effectively address the problem of antibiotic resistance at the root.

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