Therapeutic Potential of Pien-Tze-Huang: A Review on Its Chemical Composition, Pharmacology, and Clinical Application

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2019 Sep 12

PMID 31505740

Citations 15

Authors

Lili Huang

Yiping Zhang

Xiaoqin Zhang

Xiuping Chen

Yitao Wang

Jinjian Lu

Mingqing Huang

Affiliations

Soon will be listed here.

Abstract

Pien-Tze-Huang (PTH) is a famous and commonly used traditional Chinese medicine formula in China. It was first formulated by a royal physician of the Ming Dynasty (around 1555 AD). Recently, PTH has attracted attention worldwide due to its beneficial effects against various diseases, especially cancer. This paper systematically reviewed the up-to-date information on its chemical composition, pharmacology, and clinical application. A range of chemical compounds, mainly ginsenosides and bile acids, have been identified and quantified from PTH. Pharmacological studies indicated that PTH has beneficial effects against various cancers, hepatopathy, and ischemic stroke. Furthermore, PTH has been used clinically to treat various diseases in China, such as colorectal cancer, liver cancer, and hepatitis. In summary, PTH is a potential agent with extensive therapeutic effects for the treatment of various diseases. However, the lack of information on the side effects and toxicity of PTH is a non-negligible issue, which needs to be seriously studied in the future.

Citing Articles

Mechanisms of hepatic and renal injury in lipid metabolism disorders in metabolic syndrome.

Rong J, Zhang Z, Peng X, Li P, Zhao T, Zhong Y Int J Biol Sci. 2024; 20(12):4783-4798.

PMID: 39309427 PMC: 11414397. DOI: 10.7150/ijbs.100394.

Integrating RNA-sequencing and network analysis to explore the mechanism of topical Pien Tze Huang treatment on diabetic wounds.

Cao G, Tian L, Hou J, Zhang Y, Xu H, Yang H Front Pharmacol. 2024; 14:1288406.

PMID: 38293673 PMC: 10826880. DOI: 10.3389/fphar.2023.1288406.

Pien Tze Huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway.

Cao L, Liu L, Chen Y, Han Y, Wei L, Yao M Chin J Integr Med. 2024; 30(6):515-524.

PMID: 38216838 DOI: 10.1007/s11655-024-3709-5.

Immunomodulatory Function of Pien Tze Huang in T Cell-Mediated Anti-tumor Activity against B16-F10, MC38 and Hep1-6 Tumor Models.

Fu Y, Liu C, Wang J, Ji X, Tang R, Liao K Chin J Integr Med. 2024; 30(4):348-358.

PMID: 38212499 DOI: 10.1007/s11655-023-3749-2.

Evaluation and mechanism study of Pien Tze Huang against EV-A71 infection.

Wang H, Chen F, Wang S, Li Y, Liu T, Li Y Front Pharmacol. 2023; 14:1251731.

PMID: 37954857 PMC: 10637388. DOI: 10.3389/fphar.2023.1251731.

References

Fu Y, Zhang L, Hong Z, Zheng H, Li N, Gao H . Methanolic Extract of Pien Tze Huang Induces Apoptosis Signaling in Human Osteosarcoma MG63 Cells via Multiple Pathways. Molecules. 2016; 21(3):283. PMC: 6274404. DOI: 10.3390/molecules21030283. View

Lu D, Liu J, Zhao W, Li P . Chronic toxicity of ginsenoside Re on Sprague-Dawley rats. J Ethnopharmacol. 2012; 144(3):656-63. DOI: 10.1016/j.jep.2012.10.007. View

Shen A, Hong F, Liu L, Lin J, Zhuang Q, Hong Z . Effects of Pien Tze Huang on angiogenesis in vivo and in vitro. Chin J Integr Med. 2012; 18(6):431-6. DOI: 10.1007/s11655-012-1121-z. View

Huang M, Xu W, Zhang Y, Liu J, Zhang X, Lin J . Identification and quantification of the anti-inflammatory constituents in Pian-Tze-Huang by liquid chromatography combined with quadrupole time-of-flight and triple quadrupole mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016; 1027:27-39. DOI: 10.1016/j.jchromb.2016.05.021. View

Wan Y, Shen A, Qi F, Chu J, Cai Q, Sferra T . Pien Tze Huang inhibits the proliferation of colorectal cancer cells by increasing the expression of miR-34c-5p. Exp Ther Med. 2017; 14(4):3901-3907. PMC: 5639347. DOI: 10.3892/etm.2017.4972. View

Wei L, Chen P, Chen Y, Shen A, Chen H, Lin W . Pien Tze Huang suppresses the stem-like side population in colorectal cancer cells. Mol Med Rep. 2013; 9(1):261-6. DOI: 10.3892/mmr.2013.1760. View

Ning C, Gao X, Wang C, Huo X, Liu Z, Sun H . Hepatoprotective effect of ginsenoside Rg1 from Panax ginseng on carbon tetrachloride-induced acute liver injury by activating Nrf2 signaling pathway in mice. Environ Toxicol. 2018; 33(10):1050-1060. DOI: 10.1002/tox.22616. View

Shen A, Chen H, Chen Y, Lin J, Lin W, Liu L . Pien Tze Huang Overcomes Multidrug Resistance and Epithelial-Mesenchymal Transition in Human Colorectal Carcinoma Cells via Suppression of TGF-β Pathway. Evid Based Complement Alternat Med. 2014; 2014:679436. PMC: 4253702. DOI: 10.1155/2014/679436. View

Shen A, Chen Y, Hong F, Lin J, Wei L, Hong Z . Pien Tze Huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3. Oncol Rep. 2012; 28(6):2125-30. DOI: 10.3892/or.2012.2067. View

10.

Fernandez-Moriano C, Gonzalez-Burgos E, Iglesias I, Lozano R, Gomez-Serranillos M . Evaluation of the adaptogenic potential exerted by ginsenosides Rb1 and Rg1 against oxidative stress-mediated neurotoxicity in an in vitro neuronal model. PLoS One. 2017; 12(8):e0182933. PMC: 5558939. DOI: 10.1371/journal.pone.0182933. View

11.

Xu W, Zhang Y, Zhou C, Tai Y, Zhang X, Liu J . Simultaneous quantification six active compounds in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study of Pien-Tze-Huang. J Chromatogr B Analyt Technol Biomed Life Sci. 2017; 1061-1062:314-321. DOI: 10.1016/j.jchromb.2017.07.033. View

12.

Oh S, Lee J, Chang S, Shin D, Ahn K, Min B . Androstane alkaloids from musk of Moschus moschiferus. Chem Pharm Bull (Tokyo). 2002; 50(5):663-4. DOI: 10.1248/cpb.50.663. View

13.

Lu L, S M Wai M, Yew D, Mak Y . Pien Tze Huang, a composite Chinese traditional herbal extract, affects survival of neuroblastoma cells. Int J Neurosci. 2009; 119(2):255-62. DOI: 10.1080/00207450802324770. View

14.

Lin J, Wei L, Chen Y, Liu X, Hong Z, Sferra T . Pien Tze Huang induced apoptosis in human colon cancer HT-29 cells is associated with regulation of the Bcl-2 family and activation of caspase 3. Chin J Integr Med. 2011; 17(9):685-90. DOI: 10.1007/s11655-011-0846-4. View

15.

Zhuang Q, Hong F, Shen A, Zheng L, Zeng J, Lin W . Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. Int J Oncol. 2012; 40(5):1569-74. DOI: 10.3892/ijo.2012.1326. View

16.

Chen X, Qi F, Shen A, Chu J, Sferra T, Chen Y . Pien Tze Huang () Overcomes Doxorubicin Resistance and Inhibits Epithelial-Mesenchymal Transition in MCF-7/ADR Cells. Chin J Integr Med. 2018; 25(8):598-603. DOI: 10.1007/s11655-018-2992-4. View

17.

Fu C, Chu J, Shen A, Liu L, Chen H, Lin J . Pien Tze Huang alleviates 5-fluorouracil-induced intestinal mucositis in CT-26 tumor-bearing mice. Exp Ther Med. 2017; 14(3):2291-2297. PMC: 5609198. DOI: 10.3892/etm.2017.4755. View

18.

Chen H, Shen A, Zhang Y, Chen Y, Lin J, Lin W . Pien Tze Huang inhibits hypoxia-induced epithelial-mesenchymal transition in human colon carcinoma cells through suppression of the HIF-1 pathway. Exp Ther Med. 2014; 7(5):1237-1242. PMC: 3991510. DOI: 10.3892/etm.2014.1549. View

19.

Lim K, Lim D, Kim J . Ginsenoside-Re ameliorates ischemia and reperfusion injury in the heart: a hemodynamics approach. J Ginseng Res. 2013; 37(3):283-92. PMC: 3818954. DOI: 10.5142/jgr.2013.37.283. View

20.

Liu S, Cheng Y, Rao M, Tang M, Dong Z . Muscone Induces CYP1A2 and CYP3A4 Enzyme Expression in L02 Human Liver Cells and CYP1A2 and CYP3A11 Enzyme Expression in Kunming Mice. Pharmacology. 2017; 99(5-6):205-215. DOI: 10.1159/000455154. View