Association of Rs6265 and Rs17782313 with Metabolic Syndrome in Pakistanis

Overview

Journal J Biosci

Specialties Biochemistry
Biology

Date 2019 Sep 11

PMID 31502573

Citations 4

Authors

Sobia Rana

Ayesha Sultana

Adil Anwar Bhatti

Affiliations

Soon will be listed here.

Abstract

The current case-control study sought the association of BDNF rs6265 and MC4R rs17782313 with metabolic syndrome (MetS), MetS components and other related metabolic parameters in a sample of Pakistani subjects. Fasting high-density lipoprotein cholesterol (HDL-C) and homeostatic model assessment of insulin sensitivity showed a significantly lower mean whereas body mass index (BMI), waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose, insulin, total cholesterol (TC), low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, triglycerides (TG), cholesterol to HDL-C ratio, TG to HDL-C ratio, homeostatic model assessment of insulin resistance, visceral adiposity index, lipid accumulation product and the product of TG and glucose showed a significantly higher mean in the presence of MetS. Reduced HDL-C appeared as the most frequent and hypertriglyceridemia as the least frequent component of MetS whereas clustering of reduced HDL-C + abdominal obesity (AO) + hyperglycemia appeared as the most prevalent combination of MetS components. Moreover, BDNF rs6265 showed BMI and gender independent association with increased risk of MetS in Pakistani individuals whereas MC4R rs17782313 showed BMI and gender dependent association with increased risk of MetS in Pakistani females. In addition, BDNF rs6265 and MC4R rs17782313 showed gender-dependent associations with decreased risk of having low HDL-C in males and increased risk of having abdominal obesity in females, respectively. However, no association was observed for metabolic variables other than components of MetS across genotypes of both BDNF rs6265 and MC4R rs17782313.

Citing Articles

Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study.

Goldfield G, Walsh J, Sigal R, Kenny G, Hadjiyannakis S, DE Lisio M Front Neurosci. 2021; 15:715330.

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The association between BDNF levels and risperidone-induced weight gain is dependent on the BDNF Val66Met polymorphism in antipsychotic-naive first episode schizophrenia patients: a 12-week prospective study.

Liu J, Wang P, Sun L, Guan X, Xiu M, Zhang X Transl Psychiatry. 2021; 11(1):458.

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A Rare Potential Pathogenic Variant in the Gene is Found in a Brazilian Patient with Severe Childhood-Onset Obesity.

Proenca da Fonseca A, Abreu G, Palhinha L, Zembrzuski V, Junior M, Carneiro J Diabetes Metab Syndr Obes. 2021; 14:11-22.

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A Nutrigenetic Approach to Investigate the Relationship between Metabolic Traits and Vitamin D Status in an Asian Indian Population.

Alathari B, Bodhini D, Jayashri R, Lakshmipriya N, Shanthi Rani C, Sudha V Nutrients. 2020; 12(5).

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