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» Articles » PMID: 31500396

The Redox Role of G6PD in Cell Growth, Cell Death, and Cancer

Overview
Journal Cells
Publisher MDPI
Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology
Date 2019 Sep 11
PMID 31500396
Citations 114
Authors
Hung-Chi Yang
Yi-Hsuan Wu
Wei-Chen Yen
Hui-Ya Liu
Tsong-Long Hwang
Arnold Stern
Daniel Tsun-Yee Chiu
Affiliations
Soon will be listed here.
Abstract

The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase (G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in cells. NADPH also plays key roles in cellular processes mediated by redox signaling. Insufficient G6PD activity predisposes cells to growth retardation and demise. Severely lacking G6PD impairs embryonic development and delays organismal growth. Altered G6PD activity is associated with pathophysiology, such as autophagy, insulin resistance, infection, inflammation, as well as diabetes and hypertension. Aberrant activation of G6PD leads to enhanced cell proliferation and adaptation in many types of cancers. The present review aims to update the existing knowledge concerning G6PD and emphasizes how G6PD modulates redox signaling and affects cell survival and demise, particularly in diseases such as cancer. Exploiting G6PD as a potential drug target against cancer is also discussed.

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References
1.
El Assar M, Angulo J, Rodriguez-Manas L . Oxidative stress and vascular inflammation in aging. Free Radic Biol Med. 2013; 65:380-401. DOI: 10.1016/j.freeradbiomed.2013.07.003. View
2.
Kim D, Song L, Wang J, Wu H, Gou W, Cui W . Carbon Monoxide Inhibits Islet Apoptosis via Induction of Autophagy. Antioxid Redox Signal. 2017; 28(14):1309-1322. PMC: 5905947. DOI: 10.1089/ars.2016.6979. View
3.
Sen N, Paul B, Gadalla M, Mustafa A, Sen T, Xu R . Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions. Mol Cell. 2012; 45(1):13-24. PMC: 3261430. DOI: 10.1016/j.molcel.2011.10.021. View
4.
Jenwitheesuk A, Nopparat C, Mukda S, Wongchitrat P, Govitrapong P . Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways. Int J Mol Sci. 2014; 15(9):16848-84. PMC: 4200827. DOI: 10.3390/ijms150916848. View
5.
Elf S, Lin R, Xia S, Pan Y, Shan C, Wu S . Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin. Oncogene. 2016; 36(2):254-262. PMC: 5464402. DOI: 10.1038/onc.2016.196. View