The Role of Mesenchymal Stem Cells in Atherosclerosis: Prospects for Therapy Via the Modulation of Inflammatory Milieu

Overview

Journal J Clin Med

Specialty General Medicine

Date 2019 Sep 11

PMID 31500373

Citations 17

Authors

Armita Mahdavi Gorabi

Maciej Banach

Zeljko Reiner

Matteo Pirro

Saeideh Hajighasemi

Thomas P Johnston

Amirhossein Sahebkar

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis is a chronic, inflammatory disease that mainly affects the arterial intima. The disease is more prevalent in middle-age and older individuals with one or more cardiovascular risk factors, including dyslipidemia, hypertension, diabetes, smoking, obesity, and others. The beginning and development of atherosclerosis has been associated with several immune components, including infiltration of inflammatory cells, monocyte/macrophage-derived foam cells, and inflammatory cytokines and chemokines. Mesenchymal stem cells (MSCs) originate from several tissue sources of the body and have self-renewal and multipotent differentiation characteristics. They also have immunomodulatory and anti-inflammatory properties. Recently, it was shown that MSCs have a regulatory role in plasma lipid levels. In addition, MSCs have shown to have promising potential in terms of treatment strategies for several diseases, including those with an inflammatory component. In this regard, transplantation of MSCs to patients with atherosclerosis has been proposed as a novel strategy in the treatment of this disease. In this review, we summarize the current advancements regarding MSCs for the treatment of atherosclerosis.

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