Prevalence and Association of Human Papillomavirus with Esophageal Squamous Cell Carcinoma in Iran: A Systematic Review and Meta-Analysis

Overview

Journal Iran J Public Health

Date 2019 Sep 10

PMID 31497542

Citations 6

Authors

Bashir Mohammadpour

Samaneh Rouhi

Mazaher Khodabandehloo

Masoud Moradi

Affiliations

Soon will be listed here.

Abstract

Background: Human papillomavirus (HPV) can infect the epithelium of the esophagus, but so far there is no reliable and comprehensive evidence about the prevalence and association of HPV with esophageal cancer in Iran, as high incidence region. This study aimed to evaluate the prevalence and association of HPV with esophageal squamous cell carcinoma (ESCC) in Iran.

Methods: Relevant English and Persian articles published up to Aug 2017 and indexed in databases were reviewed. Frequency of HPV genotypes in ESCC cases and controls was surveyed according to regions of Iran. Data were meta-analyzed with random effects models using Comprehensive Meta-Analysis software.

Results: Overall, 14 studies were eligible including 1444 samples (1062 ESCC cases and 382 controls). HPV was positive in 269 (25.32%) of 1062 ESCC cases and in 65 (17.01%) of 382 controls. Total prevalence of HPV in both groups was estimated 0.256 (95%CI, 0.208%-0.310%). The prevalence of HPV-16 and HPV-18 was estimated 0.121 (95%CI: 0.087-0.183) and 0.046 (95%CI; 0.023-0.088), respectively. The difference in HPV prevalence in different regions of Iran was statistically significant (Q=18.20, df =4, =0.001). In 6 case-control studies, the pooled odds ratio was estimated 1.99 (95%CI; 0.916-4.315).

Conclusion: High-risk HPVs were observed in ESCC cases and controls from different regions of Iran. The odds ratio indicates that the HPV infection in ESCC cases was approximately 2 fold more than the controls. More case-control studies in other populations with larger sample size are necessary.

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References

Farhadi M, Tahmasebi Z, Merat S, Kamangar F, Nasrollahzadeh D, Malekzadeh R . Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population. World J Gastroenterol. 2005; 11(8):1200-3. PMC: 4250714. DOI: 10.3748/wjg.v11.i8.1200. View

Eslami Far A, Aghakhani A, Hamkar R, Ramezani A, Pishbigar H, Mirmomen S . Frequency of human papillomavirus infection in oesophageal squamous cell carcinoma in Iranian patients. Scand J Infect Dis. 2007; 39(1):58-62. DOI: 10.1080/00365540600740496. View

Kolahdoozan S, Sadjadi A, Radmard A, Khademi H . Five common cancers in Iran. Arch Iran Med. 2010; 13(2):143-6. View

Sitas F, Egger S, Urban M, Taylor P, Abnet C, Boffetta P . InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers. J Natl Cancer Inst. 2012; 104(2):147-58. PMC: 3260131. DOI: 10.1093/jnci/djr499. View

Abdirad A, Eram N, Heshmatzade Behzadi A, Koriyama C, Parvaneh N, Akiba S . Human papillomavirus detected in esophageal squamous cell carcinoma in Iran. Eur J Intern Med. 2012; 23(2):e59-62. DOI: 10.1016/j.ejim.2011.06.011. View

Yahyapour Y, Shamsi-Shahrabadi M, Mahmoudi M, Siadati S, Shahryar S, Shokri-Shirvani J . Evaluation of human papilloma virus infection in patients with esophageal squamous cell carcinoma from the Caspian Sea area, north of Iran. Asian Pac J Cancer Prev. 2012; 13(4):1261-6. DOI: 10.7314/apjcp.2012.13.4.1261. View

Syrjanen K . Geographic origin is a significant determinant of human papillomavirus prevalence in oesophageal squamous cell carcinoma: systematic review and meta-analysis. Scand J Infect Dis. 2012; 45(1):1-18. DOI: 10.3109/00365548.2012.702281. View

Noori S, Monabati A, Ghaderi A . The prevalence of human papilloma virus in esophageal squamous cell carcinoma. Iran J Med Sci. 2012; 37(2):126-33. PMC: 3470072. View

Yahyapour Y, Shamsi-Shahrabadi M, Mahmoudi M, Motevallian A, Siadati S, Shefaii S . High-risk and low-risk human papillomavirus in esophageal squamous cell carcinoma at Mazandaran, Northern Iran. Pathol Oncol Res. 2012; 19(3):385-91. DOI: 10.1007/s12253-012-9590-0. View

10.

Seifi S, Asvadi Kermani I, Dolatkhah R, Asvadi Kermani A, Sakhinia E, Asgarzadeh M . Prevalence of oral human papilloma virus in healthy individuals in East azerbaijan province of iran. Iran J Public Health. 2013; 42(1):79-85. PMC: 3595626. View

11.

Liyanage S, Rahman B, Ridda I, Newall A, Tabrizi S, Garland S . The aetiological role of human papillomavirus in oesophageal squamous cell carcinoma: a meta-analysis. PLoS One. 2013; 8(7):e69238. PMC: 3722293. DOI: 10.1371/journal.pone.0069238. View

12.

Yong F, Xudong N, Lijie T . Human papillomavirus types 16 and 18 in esophagus squamous cell carcinoma: a meta-analysis. Ann Epidemiol. 2013; 23(11):726-34. DOI: 10.1016/j.annepidem.2013.07.002. View

13.

Li X, Gao C, Yang Y, Zhou F, Li M, Jin Q . Systematic review with meta-analysis: the association between human papillomavirus infection and oesophageal cancer. Aliment Pharmacol Ther. 2013; 39(3):270-81. DOI: 10.1111/apt.12574. View

14.

Petrick J, Wyss A, Butler A, Cummings C, Sun X, Poole C . Prevalence of human papillomavirus among oesophageal squamous cell carcinoma cases: systematic review and meta-analysis. Br J Cancer. 2014; 110(9):2369-77. PMC: 4007246. DOI: 10.1038/bjc.2014.96. View

15.

Hardefeldt H, Cox M, Eslick G . Association between human papillomavirus (HPV) and oesophageal squamous cell carcinoma: a meta-analysis. Epidemiol Infect. 2014; 142(6):1119-37. PMC: 9151180. DOI: 10.1017/S0950268814000016. View

16.

Haeri H, Mardani O, Asadi-Amoli F, Shahsiah R . Human papilloma virus and esophageal squamous cell carcinoma. Acta Med Iran. 2014; 52(3):197-200. View

17.

Jalilvand S, Shoja Z, Hamkar R . Human papillomavirus burden in different cancers in Iran: a systematic assessment. Asian Pac J Cancer Prev. 2014; 15(17):7029-35. DOI: 10.7314/apjcp.2014.15.17.7029. View

18.

Zhang S, Guo L, Chen Q, Zhang M, Liu S, Quan P . Prevalence of human papillomavirus 16 in esophageal cancer among the Chinese population: a systematic review and meta-analysis. Asian Pac J Cancer Prev. 2015; 15(23):10143-9. DOI: 10.7314/apjcp.2014.15.23.10143. View

19.

Zhang S, Guo L, Chen Q, Zhang M, Liu S, Quan P . The association between human papillomavirus 16 and esophageal cancer in Chinese population: a meta-analysis. BMC Cancer. 2015; 15:1096. PMC: 4352244. DOI: 10.1186/s12885-015-1096-1. View

20.

Soheili F, Heidary N, Rahbar M, Nikkho B, Fotouhi O, Afkhamzadeh A . Human papillomavirus and its clinical relevance in oesophageal squamous cell carcinoma in a Kurdish population in the west of Iran. Infect Dis (Lond). 2015; 48(4):270-273. DOI: 10.3109/23744235.2015.1109134. View