Circ_0039569 Promotes Renal Cell Carcinoma Growth and Metastasis by Regulating MiR-34a-5p/CCL22

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2019 Sep 10

PMID 31497210

Citations 36

Authors

Chengluo Jin

Linmei Shi

Zhexun Li

Wei Liu

Bai Zhao

Yu Qiu

Yakun Zhao

Kunlun Li

Yifei Li

Qingguo Zhu

Affiliations

Soon will be listed here.

Abstract

Circular RNAs (circRNAs) belong to non-coding RNAs and are known as key regulators in gene regulation. CircRNAs involve in the various biological processes of cancer. However, the functions of circRNAs in renal cell carcinoma (RCC) are still not clear. In this study, the circRNA expression profile was performed in the RCC tissues by microarray. There were 35 significantly expressed circRNAs with more than 5 folds from microarray analysis. Hsa_circ_0039569 (circ_0039569) was verified to be up-regulated in RCC and cells compared with the controls by real time RT-PCR. The assays of cellular functions showed that circ_0039569 down-regulation suppressed the proliferation and metastasis of RCC cells. The molecular mechanism of circ_0039569 in RCC cells showed that circ_0039569 promoted RCC progression by up-regulating CCL22 expression via down-regulating miR-34a-5p. Taken together, the study indicated that circ_0039569 played an important role in RCC cell survival and metastasis, which suggested that an oncogenic role of circ_0039569 in RCC progression.

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