Central Nicotine Induces Browning Through Hypothalamic κ Opioid Receptor

Overview

Journal Nat Commun

Specialty Biology

Date 2019 Sep 8

PMID 31492869

Citations 18

Authors

Patricia Seoane-Collazo

Laura Linares-Pose

Eva Rial-Pensado

Amparo Romero-Pico

Jose Maria Moreno-Navarrete

Noelia Martinez-Sanchez

Pablo Garrido-Gil

Ramon Iglesias-Rey

Donald A Morgan

Naoki Tomasini

Samuel Andrew Malone

Ana Senra

Cintia Folgueira

Gema Medina-Gomez

Tomas Sobrino

Jose L Labandeira-Garcia

Ruben Nogueiras

Ana I Domingos

Jose-Manuel Fernandez-Real

Kamal Rahmouni

Carlos Dieguez

Miguel Lopez

Affiliations

Soon will be listed here.

Abstract

Increased body weight is a major factor that interferes with smoking cessation. Nicotine, the main bioactive compound in tobacco, has been demonstrated to have an impact on energy balance, since it affects both feeding and energy expenditure at the central level. Among the central actions of nicotine on body weight, much attention has been focused on its effect on brown adipose tissue (BAT) thermogenesis, though its effect on browning of white adipose tissue (WAT) is unclear. Here, we show that nicotine induces the browning of WAT through a central mechanism and that this effect is dependent on the κ opioid receptor (KOR), specifically in the lateral hypothalamic area (LHA). Consistent with these findings, smokers show higher levels of uncoupling protein 1 (UCP1) expression in WAT, which correlates with smoking status. These data demonstrate that central nicotine-induced modulation of WAT browning may be a target against human obesity.

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