Long-Term Outcomes of Pulmonary Resection for Lung Cancer Patients with Chronic Kidney Disease

Overview

Journal World J Surg

Publisher Wiley

Specialty General Surgery

Date 2019 Sep 6

PMID 31485810

Citations 3

Authors

Yoko Yamamoto

Ryu Kanzaki

Takashi Kanou

Naoko Ose

Soichiro Funaki

Masato Minami

Yasushi Shintani

Affiliations

Soon will be listed here.

Abstract

Background: The survival outcome in lung cancer patients with chronic kidney disease (CKD) has not been well evaluated. The aim of this study was to evaluate the survival outcomes following non-small cell lung cancer (NSCLC) surgery in patients with CKD as a preoperative comorbidity.

Methods: Among 671 patients who underwent surgery for NSCLC between 2007 and 2014 at our hospital, 55 (8%) had CKD and we retrospectively analyzed the survival outcomes of these patients.

Results: Most patients with CKD were elderly and male. Patients with CKD had a higher frequency of smoking habit, cardiovascular disease, and pulmonary diseases, and a notably lower pulmonary function, resulting in receiving limited pulmonary resection. There were no marked differences in the frequency of surgical complications between patients with and without CKD (p = 0.16). Squamous cell carcinoma was more frequently diagnosed in patients with CKD than in those without it. The 5-year disease-free survival rates in patients with and without CKD were 60.0% and 69.7% (p = 0.06), respectively, and the 5-year overall survival rates were 68.9% and 80.0%, respectively, showing significant differences (p = 0.01). The rate of receiving supportive care was higher in patients with CKD when recurrence observed.

Conclusion: CKD is associated with a poorer overall survival in patients who undergo lung cancer resection for recurrent disease. As patients with CKD tend to have a poor respiratory function, thoracic surgeons should carefully select the resection type to balance the therapeutic benefit and invasiveness.

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References

Goldstraw P, Crowley J, Chansky K, Giroux D, Groome P, Rami-Porta R . The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol. 2007; 2(8):706-14. DOI: 10.1097/JTO.0b013e31812f3c1a. View

Ikezoe K, Handa T, Tanizawa K, Yokoi H, Kubo T, Aihara K . Chronic Kidney Disease Predicts Survival in Patients with Idiopathic Pulmonary Fibrosis. Respiration. 2017; 94(4):346-354. DOI: 10.1159/000478787. View

Japan nephrology society . [Special issue: Clinical practice guidebook for diagnosis and treatment of chronic kidney disease 2012]. Nihon Jinzo Gakkai Shi. 2013; 54(8):1034-191. View

Karampitsakos T, Tzilas V, Tringidou R, Steiropoulos P, Aidinis V, Papiris S . Lung cancer in patients with idiopathic pulmonary fibrosis. Pulm Pharmacol Ther. 2017; 45:1-10. DOI: 10.1016/j.pupt.2017.03.016. View

Matsumoto S, Takayama T, Wakatsuki K, Tanaka T, Migita K, Nakajima Y . Short-term and long-term outcomes after gastrectomy for gastric cancer in patients with chronic kidney disease. World J Surg. 2014; 38(6):1453-60. DOI: 10.1007/s00268-013-2436-4. View

Lee C, Hsieh S, Lin J, Liu M, Yen T . Hepatocellular carcinoma in patients with chronic kidney disease. World J Gastroenterol. 2013; 19(16):2466-72. PMC: 3646136. DOI: 10.3748/wjg.v19.i16.2466. View

Inamoto H, Ozaki R, Matsuzaki T, Wakui M, Saruta T, Osawa A . Incidence and mortality patterns of malignancy and factors affecting the risk of malignancy in dialysis patients. Nephron. 1991; 59(4):611-7. DOI: 10.1159/000186652. View

Antoniak D, Are C, Vokoun C, Samson K, Smith L, Shiffermiller J . The Relationship Between Age and Chronic Kidney Disease in Patients Undergoing Pancreatic Resection. J Gastrointest Surg. 2018; 22(8):1376-1384. DOI: 10.1007/s11605-018-3743-8. View

Patel P, Henry L, Ganti A, Potti A . Clinical course of lung cancer in patients with chronic kidney disease. Lung Cancer. 2004; 43(3):297-300. DOI: 10.1016/j.lungcan.2003.08.029. View

10.

Nathan S, Basavaraj A, Reichner C, Shlobin O, Ahmad S, Kiernan J . Prevalence and impact of coronary artery disease in idiopathic pulmonary fibrosis. Respir Med. 2010; 104(7):1035-41. DOI: 10.1016/j.rmed.2010.02.008. View

11.

Egawa H, Furukawa K, Preston D, Funamoto S, Yonehara S, Matsuo T . Radiation and smoking effects on lung cancer incidence by histological types among atomic bomb survivors. Radiat Res. 2012; 178(3):191-201. PMC: 4031371. DOI: 10.1667/rr2819.1. View

12.

Ishigami J, Grams M, Chang A, Carrero J, Coresh J, Matsushita K . CKD and Risk for Hospitalization With Infection: The Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis. 2016; 69(6):752-761. PMC: 5438909. DOI: 10.1053/j.ajkd.2016.09.018. View

13.

James M, Hemmelgarn B, Tonelli M . Early recognition and prevention of chronic kidney disease. Lancet. 2010; 375(9722):1296-309. DOI: 10.1016/S0140-6736(09)62004-3. View

14.

Kanzaki R, Inoue M, Minami M, Shintani Y, Funaki S, Kawamura T . Outcomes of lung cancer surgery in patients with coronary artery disease: a decade of experience at a single institution. Surg Today. 2016; 47(1):27-34. DOI: 10.1007/s00595-016-1355-z. View

15.

James M, Quan H, Tonelli M, Manns B, Faris P, Laupland K . CKD and risk of hospitalization and death with pneumonia. Am J Kidney Dis. 2009; 54(1):24-32. DOI: 10.1053/j.ajkd.2009.04.005. View

16.

Nozawa H, Kitayama J, Sunami E, Watanabe T . Impact of chronic kidney disease on outcomes of surgical resection for primary colorectal cancer: a retrospective cohort review. Dis Colon Rectum. 2012; 55(9):948-56. DOI: 10.1097/DCR.0b013e3182600db7. View

17.

Katayama H, Kurokawa Y, Nakamura K, Ito H, Kanemitsu Y, Masuda N . Extended Clavien-Dindo classification of surgical complications: Japan Clinical Oncology Group postoperative complications criteria. Surg Today. 2015; 46(6):668-85. PMC: 4848327. DOI: 10.1007/s00595-015-1236-x. View

18.

Adachi H, Sakamaki K, Nishii T, Yamamoto T, Nagashima T, Ishikawa Y . Lobe-Specific Lymph Node Dissection as a Standard Procedure in Surgery for Non-Small Cell Lung Cancer: A Propensity Score Matching Study. J Thorac Oncol. 2016; 12(1):85-93. DOI: 10.1016/j.jtho.2016.08.127. View

19.

Homma A, Hayashi R, Kawabata K, Fujii T, Iwae S, Hasegawa Y . Association of impaired renal function and poor prognosis in oropharyngeal squamous cell carcinoma. Head Neck. 2016; 38(10):1495-500. DOI: 10.1002/hed.24467. View

20.

Cenik B, Sun H, Gerber D . Impact of renal function on treatment options and outcomes in advanced non-small cell lung cancer. Lung Cancer. 2013; 80(3):326-32. PMC: 3646907. DOI: 10.1016/j.lungcan.2013.02.011. View