Angiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential

Overview

Journal J Diabetes Res

Publisher Wiley

Specialty Endocrinology

Date 2019 Sep 6

PMID 31485452

Citations 24

Authors

Michael Whitehead

Andrew Osborne

Peter S Widdowson

Patrick Yu-Wai-Man

Keith R Martin

Affiliations

Soon will be listed here.

Abstract

Diabetic retinopathy (DR) is the commonest cause of blindness in the working-age population of the developed world. The molecular pathophysiology of DR is complex, and a complete spatiotemporal model of the disease is still being elucidated. Recently, a role for angiopoietin (Ang) proteins in the pathophysiology of DR has been proposed by several research groups, and several aspects of Ang signalling are being explored as novel therapeutic strategies. Here, we review the role of the Ang proteins in two important forms of DR, diabetic macular oedema and proliferative diabetic retinopathy. The function of the Ang proteins in regulating blood vessel permeability and neovascularisation is discussed, and we also evaluate recent preclinical and clinical studies highlighting the potential benefits of modulating Ang signalling as a treatment for DR.

Citing Articles

Molecular and Cellular Mechanisms Involved in the Pathophysiology of Retinal Vascular Disease-Interplay Between Inflammation and Oxidative Stress.

Srejovic J, Muric M, Jakovljevic V, Srejovic I, Sreckovic S, Petrovic N Int J Mol Sci. 2024; 25(21).

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Eucalyptol Ameliorates Retinal Microvascular Defects through Modulating ER Stress and Angiopoietin-Tie Signaling in Diabetic Eyes.

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Biochemical Changes in Anterior Chamber of the Eye in Diabetic Patients-A Review.

Dolar-Szczasny J, Drab A, Rejdak R J Clin Med. 2024; 13(9).

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Mapping the daily rhythmic transcriptome in the diabetic retina.

Silk R, Winter H, Dkhissi-Benyahya O, Evans-Molina C, Stitt A, Tiwari V Vision Res. 2023; 214:108339.

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