Antivirals and Vaccines for Enterovirus A71

Overview

Journal J Biomed Sci

Publisher Biomed Central

Specialty Biology

Date 2019 Sep 5

PMID 31481071

Citations 37

Authors

Jing-Yi Lin

Yu-An Kung

Shin-Ru Shih

Affiliations

Soon will be listed here.

Abstract

Enterovirus A71 (EV-A71) is an important emerging virus posing a threat to children under five years old. EV-A71 infection in infants or young children can cause hand-foot-and-mouth disease, herpangina, or severe neurological complications. However, there are still no effective antivirals for treatment of these infections. In this review, we summarize the antiviral compounds developed to date based on various targets of the EV-A71 life cycle. Moreover, development of a vaccine would be the most effective approach to prevent EV-A71 infection. Therefore, we also summarize the development and clinical progress of various candidate EV-A71 vaccines, including inactivated whole virus, recombinant VP1 protein, synthetic peptides, viral-like particles, and live attenuated vaccines.

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