» Articles » PMID: 31472877

Chitosan-coated Liposomes to Stabilize and Enhance Transdermal Delivery of Indocyanine Green for Photodynamic Therapy of Melanoma

Overview
Journal Carbohydr Polym
Specialty Biochemistry
Date 2019 Sep 2
PMID 31472877
Citations 49
Authors
Affiliations
Soon will be listed here.
Abstract

Indocyanine green (ICG) has been used clinically and noticed as a promising candidate for the topical melanoma photodynamic therapy (PDT). Despite its high potentials in topical PDT, the use of ICG has been hampered by the instability in aqueous solution. In the present study, chitosan-coated liposomes were adopted as a formulation strategy which could stabilize and enhance skin permeation of ICG. Chitosan-coating was verified by the significantly increased liposomal size and reversed zeta potential from negative to positive value by positive chitosan coating. Chitosan-coating liposomes protected ICG from degradation while uncoated liposomes did not. Moreover, they significantly increased cellular uptake and photocytotoxicity of ICG in B16-F10 melanoma cells in a chitosan-dependent manner. The skin permeation of ICG was also drastically improved by chitosan-coated liposomes. These findings emphasize the promising potential of ICG-loaded chitosan-coated liposomes for topical PDT of melanoma.

Citing Articles

Penetration of Microplastics and Nanoparticles Through Skin: Effects of Size, Shape, and Surface Chemistry.

Menichetti A, Mordini D, Montalti M J Xenobiot. 2025; 15(1.

PMID: 39846538 PMC: 11755607. DOI: 10.3390/jox15010006.


Recent progress in topical and transdermal approaches for melanoma treatment.

Yourdkhani A, Esfandyari-Manesh M, Ranjbaran P, Amani M, Dinarvand R Drug Deliv Transl Res. 2024; .

PMID: 39653958 DOI: 10.1007/s13346-024-01738-z.


Nanocarrier-Based Transdermal Drug Delivery Systems for Dermatological Therapy.

Kang Y, Zhang S, Wang G, Yan Z, Wu G, Tang L Pharmaceutics. 2024; 16(11).

PMID: 39598508 PMC: 11597219. DOI: 10.3390/pharmaceutics16111384.


Advancements in skin cancer treatment: focus on photodynamic therapy: a review.

Xu M, Kong L, Jamil M Am J Cancer Res. 2024; 14(10):5011-5044.

PMID: 39553219 PMC: 11560809. DOI: 10.62347/JOUT3260.


Advances in smart nanotechnology-supported photodynamic therapy for cancer.

Li G, Wang C, Jin B, Sun T, Sun K, Wang S Cell Death Discov. 2024; 10(1):466.

PMID: 39528439 PMC: 11554787. DOI: 10.1038/s41420-024-02236-4.