Surfactant Protein D Is Altered in Experimental Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome

Overview

Journal J Trop Med

Publisher Wiley

Specialty Tropical Medicine

Date 2019 Aug 31

PMID 31467567

Citations 2

Authors

Chuchard Punsawad

Parnpen Viriyavejakul

Tachpon Techarang

Affiliations

Soon will be listed here.

Abstract

Surfactant protein D (SP-D) is in the collectin family of C-type lectins and plays an important role in the regulation of inflammation and the innate immune defense against pathogens. This protein has been proposed as a biomarker for acute lung injury. However, the expression of SP-D in the lung and the circulating levels of SP-D during malaria infection have received limited attention. Therefore, the aim of this study was to determine the location and expression of the SP-D protein in lung tissue and to measure the plasma level of SP-D in experimental malaria-associated acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Malaria-infected mice induced by ANKA were classified into two groups, namely, the ALI/ARDS and non-ALI/ARDS groups, according to lung histopathology. The lungs of uninfected mice were used as a control group. The location and expression of SP-D in the lung tissues were investigated by immunohistochemical staining and Western blot analysis. In addition, the level of SP-D in plasma and lung homogenate was measured by an enzyme-linked immunosorbent assay. Immunohistochemical staining of SP-D was significantly increased in the lung tissues of the malaria-infected mice in the ALI/ARDS group compared with that in the malaria-infected mice in the non-ALI/ARDS group and the mice in the control group ( < 0.05). The levels of SP-D in the plasma and lung homogenate were significantly increased in the malaria-infected mice in the ALI/ARDS group compared with those in the malaria-infected mice in the non-ALI/ARDS group and the mice in the control group ( < 0.05). There was a significant positive correlation between SP-D in the plasma and SP-D in the lung homogenate ( = 0.900, = 0.037). In conclusion, this study demonstrated increased expression levels of SP-D in the lung tissue and high levels of plasma SP-D in the malaria-infected mice with ALI/ARDS compared with those in the mice in the other groups. The current study supports that the elevation of the plasma SP-D level may provide useful biological confirmation of the diagnosis of ALI/ARDS during malaria infection.

Citing Articles

Circulating Surfactant Protein D: A Biomarker for Acute Lung Injury?.

Elmore A, Almuntashiri A, Wang X, Almuntashiri S, Zhang D Biomedicines. 2023; 11(9.

PMID: 37760958 PMC: 10525947. DOI: 10.3390/biomedicines11092517.

The effect of N6-methyladenosine (m6A) factors on the development of acute respiratory distress syndrome in the mouse model.

Fei L, Sun G, Sun J, Wu D Bioengineered. 2022; 13(3):7622-7634.

PMID: 35263199 PMC: 8973778. DOI: 10.1080/21655979.2022.2049473.

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