Novel Brönsted Acidic Ionic Liquids Confined in UiO-66 Nanocages for the Synthesis of Dihydropyrido[2,3-]Pyrimidine Derivatives Under Solvent-Free Conditions

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2019 Aug 29

PMID 31460153

Citations 9

Authors

Boshra Mirhosseini-Eshkevari

Manzarbanoo Esnaashari

Mohammad Ali Ghasemzadeh

Affiliations

Soon will be listed here.

Abstract

The effective and simple one-pot, three-component protocol for the synthesis of dihydropyrido[2,3-]pyrimidine derivatives is presented using a triethylenediamine or imidazole Brönsted acidic, ionic-liquid-supported Zr metal-organic framework (TEDA/IMIZ-BAIL@UiO-66) as a green, novel, and retrievable heterogeneous catalyst under mild conditions. The multicomponent reactions of 6-amino-1,3-dimethyl uracil, various aromatic aldehydes, and acetyl acetone were conducted under solvent-free conditions so that dihydropyrido[2,3-]pyrimidine derivatives can be obtained. It is possible to separate and purify the respective products easily using crystallization. We can recycle the catalysts six times without losing any major activity. Also, the characterization of the catalyst was done by energy-dispersive X-ray, field emission scanning electron microscopy, Fourier transform infrared, Brunauer-Emmett-Teller, X-ray diffraction, and thermogravimetric analysis analyses.

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