Chest Magnetic Resonance Imaging Decreases Inter-observer Variability of Gross Target Volume for Lung Tumors

Overview

Journal Front Oncol

Specialty Oncology

Date 2019 Aug 29

PMID 31456936

Citations 5

Authors

Laurent Basson

Hajer Jarraya

Alexandre Escande

Abel Cordoba

Rayyan Daghistani

David Pasquier

Thomas Lacornerie

Eric Lartigau

Xavier Mirabel

Affiliations

Soon will be listed here.

Abstract

PET/CT is a standard medical imaging used in the delineation of gross tumor volume (GTV) in case of radiation therapy for lung tumors. However, PET/CT could present some limitations such as resolution and standardized uptake value threshold. Moreover, chest MRI has shown good potential in diagnosis for thoracic oncology. Therefore, we investigated the influence of chest MRI on inter-observer variability of GTV delineation. Five observers contoured the GTV on CT for 14 poorly defined lung tumors during three contouring phases based on true daily clinical routine and acquisition: CT phase, with only CT images; PET phase, with PET/CT; and MRI phase, with both PET/CT and MRI. Observers waited at least 1 week between each phases to decrease memory bias. Contours were compared using descriptive statistics of volume, coefficient of variation (COV), and Dice similarity coefficient (DSC). MRI phase volumes (median 4.8 cm) were significantly smaller than PET phase volumes (median 6.4 cm, = 0.015), but not different from CT phase volumes (median 5.7 cm, = 0.30). The mean COV was improved for the MRI phase (0.38) compared to the CT (0.58, = 0.024) and PET (0.53, = 0.060) phases. The mean DSC of the MRI phase (0.67) was superior to those of the CT and PET phases (0.56 and 0.60, respectively; < 0.001 for both). The addition of chest MRI seems to decrease inter-observer variability of GTV delineation for poorly defined lung tumors compared to PET/CT alone and should be explored in further prospective studies.

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