Effect of Topical Rifamycin Application on Epidural Fibrosis in Rats

Overview

Journal Turk J Phys Med Rehabil

Specialty Rehabilitation Medicine

Date 2019 Aug 28

PMID 31453541

Citations 1

Authors

Cem Dinc

Cengiz Tuncer

Mehmet Erhan Turkoglu

Mehmet Tokmak

Pinar Ocak

Uygur Er

Affiliations

Soon will be listed here.

Abstract

Objectives: This study aims to investigate the effects of topical rifamycin SV application on epidural fibrosis formation in a rat model.

Materials And Methods: Between March 2015 and April 2015, a total of 20 Wistar rats were equally and randomly divided into laminectomy only group (control group) and laminectomy and rifamycin SV group (treatment group). Laminectomy was performed between L3-L5 in all rats. Surgical field was irrigated with 1 mL rifamycin SV (1 mL). After four weeks, vertebral columns of the rats were removed en bloc between the L1 and L5 levels, and epidural fibrosis and arachnoid involvement were histopathologically evaluated and graded.

Results: Grade 3 epidural fibrosis formation ratio was lower in the treatment group (40%) compared to the control group (80%). However, there was no statistically significant difference between the treatment and control groups in terms of epidural fibrosis (p=0.164) and arachnoid involvement (p=0.303).

Conclusion: Intraoperative rifamycin irrigation tends to reduce epidural fibrosis formation risk, although not statistically significant.

Citing Articles

An Evidence Based Review of Epidurolysis for the Management of Epidural Adhesions.

Urits I, Schwartz R, Brinkman J, Foster L, Miro P, Berger A Psychopharmacol Bull. 2021; 50(4 Suppl 1):74-90.

PMID: 33633419 PMC: 7901122.

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