Voluntary Medical Male Circumcision and HIV Infection Among Men Who Have Sex with Men: Implications from a Systematic Review

Overview

Journal SAGE Open Med

Publisher Sage Publications

Specialty General Medicine

Date 2019 Aug 27

PMID 31448119

Citations 4

Authors

Chen Zhang

Han-Zhu Qian

Yu Liu

Sten H Vermund

Affiliations

Soon will be listed here.

Abstract

Background: With the rapidly-increased HIV epidemic among men who have sex with men worldwide, the effectiveness of voluntary medical male circumcision as the tool of HIV prevention still remains undetermined.

Purpose: In the current study, we conducted a systematic review and meta-analysis to assess the association between voluntary medical male circumcision and HIV risk among men who have sex with men.

Methods And Conclusion: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline, we conducted a comprehensive literature search through multiple databases. A total of 37 articles/abstracts were included in the analysis. We employed random-effects models and subgroup analyses based upon key study characteristics derived from empirical studies. A total of 117,293 men who have sex with men were included in the meta-analysis, and no randomized control trials have been identified. The odds of being HIV positive were 7% lower among men who have sex with men who were circumcised than among men who have sex with men who were uncircumcised (adjusted odds ratio, 0.93; 95% confidence interval, 0.88-0.99). The evidence for the potential protective effect of voluntary medical male circumcision was stronger among men who have sex with men in Asia and Africa (adjusted odds ratio, 0.62; 95% confidence interval, 0.53-0.73). Our meta-analyses may suggest a protective effect of voluntary medical male circumcision against HIV infection among men who have sex with men, especially in settings like Asia/Africa.

Citing Articles

Deficits and opportunities, pivots and shifts for scaling-up voluntary medical male circumcision in Uganda: a qualitative reflexive thematic analysis study.

Byabagambi J, Hollingsworth B, Limmer M BMC Public Health. 2024; 24(1):2232.

PMID: 39152417 PMC: 11329999. DOI: 10.1186/s12889-024-19796-w.

Spiraling Risk: Visualizing the multilevel factors that socially pattern HIV risk among gay, bisexual & other men who have sex with men using Complex Systems Theory.

Stojanovski K, King E, OConnell S, Gallagher K, Theall K, Geronimus A Curr HIV/AIDS Rep. 2023; 20(4):206-217.

PMID: 37486568 PMC: 10403445. DOI: 10.1007/s11904-023-00664-y.

Voluntary Medical Male Circumcision and Incident HIV Infection Among Men Who Have Sex With Men in China (The CoM Study): Protocol for a Randomized Controlled Trial.

Gao Y, Zheng W, Sun Y, Yang L, Guo Z, Li Y JMIR Res Protoc. 2023; 12:e47160.

PMID: 37247211 PMC: 10262017. DOI: 10.2196/47160.

Predicting the long-term impact of voluntary medical male circumcision on HIV incidence among men who have sex with men in Beijing, China.

Zhang C, Webb G, Lou J, Shepherd B, Qian H, Liu Y AIDS Care. 2019; 32(3):343-353.

PMID: 31619058 PMC: 6981072. DOI: 10.1080/09540121.2019.1679704.

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