First Visualization of the Human Subarachnoid Space and Brain Cortex Optical Coherence Tomography

Overview

Journal Ther Adv Neurol Disord

Specialty Neurology

Date 2019 Aug 27

PMID 31447933

Citations 11

Authors

Karl Hartmann

Klaus-Peter Stein

Belal Neyazi

Ibrahim Erol Sandalcioglu

Affiliations

Soon will be listed here.

Abstract

The present work explores optical coherence tomography (OCT) as a suitable neuroimaging modality of the subarachnoid space (SAS). Patients ( = 26) with frontolateral craniotomy were recruited. The temporal and frontal arachnoid mater and adjacent anatomical structures were scanned using microscope-integrated three-dimensional OCT, (iOCT). Analysis revealed a detailed depiction of the SAS (76.9%) with delineation of the internal microanatomical structures such as the arachnoid barrier cell membrane (ABCM; 96.2%), trabecular system (50.2%), internal blood vessels (96.2%), pia mater (26.9%) and the brain cortex (96.2%). Orthogonal distance measuring was possible. The SAS showed a mean depth of 570 µm frontotemporal. The ABCM showed a mean depth of 74 µm frontotemporal. These results indicate that OCT provides a dynamic, non-invasive tool for real-time imaging of the SAS and adjacent anatomical structures at micrometer spatial resolution. Further studies are necessary to evaluate the value of OCT during microsurgical procedures.

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