Exploring New Applications of Tulip Tree (Liriodendron Tulipifera L.): Leaf Essential Oil As Apoptotic Agent for Human Glioblastoma

Overview

Journal Environ Sci Pollut Res Int

Publisher Springer

Specialties Environmental Health
Toxicology

Date 2019 Aug 25

PMID 31444719

Citations 5

Authors

Luana Quassinti

Filippo Maggi

Federica Ortolani

Giulio Lupidi

Dezemona Petrelli

Luca A Vitali

Antonino Miano

Massimo Bramucci

Affiliations

Soon will be listed here.

Abstract

Liriodendron tulipifera L. (Magnoliaceae), also known as "tulip tree," is a hardwood plant native to North America, cultivated all over the world and used on an industrial level, especially for its fine wood and to make honey. It has also been traditionally exploited for its antimalarial properties. However, our knowledge about the bioactivity of its essential oil remains patchy. In this research, we focused on the biological evaluation of the volatile fractions obtained from different parts of the plant which are normally discharged by industry, including leaves, flowers, and fruits. For the purpose, the essential oils were obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS). Then, they were evaluated as radical scavenging, antioxidant, antimicrobial, and antiproliferative agents by using DPPH, ABTS, FRAP, disk diffusion, and MTT methods, respectively. The significant toxicity exhibited on human tumor cells, namely A375 malignant melanoma, HCT116 colon carcinoma, MDA-MB 231 breast adenocarcinoma, and T98G glioblastoma multiforme cell lines, prompted us to study the mechanism of action by acridine orange/ethidium bromide double staining and caspase 3 assays. Our findings shed light on the potential applications of tulip tree derivatives as anticancer drugs.

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References

Benelli G . Plant-borne compounds and nanoparticles: challenges for medicine, parasitology and entomology. Environ Sci Pollut Res Int. 2018; 25(11):10149-10150. DOI: 10.1007/s11356-017-9960-y. View

Ornano L, Venditti A, Ballero M, Sanna C, Quassinti L, Bramucci M . Chemopreventive and antioxidant activity of the chamazulene-rich essential oil obtained from Artemisia arborescens L. growing on the Isle of La Maddalena, Sardinia, Italy. Chem Biodivers. 2013; 10(8):1464-74. DOI: 10.1002/cbdv.201200435. View

Li Q, Wang G, Huang F, Li J, Cuff C, Reed E . Sensitization of lung cancer cells to cisplatin by β-elemene is mediated through blockade of cell cycle progression: antitumor efficacies of β-elemene and its synthetic analogs. Med Oncol. 2013; 30(1):488. DOI: 10.1007/s12032-013-0488-9. View

Brunetti A, Marinelli O, Morelli M, Iannarelli R, Amantini C, Russotti D . Isofuranodiene synergizes with temozolomide in inducing glioma cells death. Phytomedicine. 2019; 52:51-59. DOI: 10.1016/j.phymed.2018.09.220. View

Ngahang Kamte S, Ranjbarian F, Cianfaglione K, Sut S, DallAcqua S, Bruno M . Identification of highly effective antitrypanosomal compounds in essential oils from the Apiaceae family. Ecotoxicol Environ Saf. 2018; 156:154-165. DOI: 10.1016/j.ecoenv.2018.03.032. View

Liu K, Liu P, Liu R, Wu X . Dual AO/EB staining to detect apoptosis in osteosarcoma cells compared with flow cytometry. Med Sci Monit Basic Res. 2015; 21:15-20. PMC: 4332266. DOI: 10.12659/MSMBR.893327. View

Chiu C, Chou H, Wu P, Chen H, Wang H, Chen C . Bio-functional constituents from the stems of Liriodendron tulipifera. Molecules. 2012; 17(4):4357-72. PMC: 6268983. DOI: 10.3390/molecules17044357. View

Arevalo A, Erices J, Uribe D, Howden J, Niechi I, Munoz S . Current Therapeutic Alternatives and New Perspectives in Glioblastoma Multiforme. Curr Med Chem. 2017; 24(25):2781-2795. DOI: 10.2174/0929867324666170303122241. View

Zhu T, Xu Y, Dong B, Zhang J, Wei Z, Xu Y . β-elemene inhibits proliferation of human glioblastoma cells through the activation of glia maturation factor β and induces sensitization to cisplatin. Oncol Rep. 2011; 26(2):405-13. DOI: 10.3892/or.2011.1276. View

10.

Amorati R, Foti M, Valgimigli L . Antioxidant activity of essential oils. J Agric Food Chem. 2013; 61(46):10835-47. DOI: 10.1021/jf403496k. View

11.

Miller S, Villanueva H, Palazzo M, Wright B, Setzer W . Seasonal variation and bioactivity in the leaf oil of Liriodendron tulipifera growing in Huntsville, Alabama. Nat Prod Commun. 2009; 4(6):839-43. View

12.

Ribble D, Goldstein N, Norris D, Shellman Y . A simple technique for quantifying apoptosis in 96-well plates. BMC Biotechnol. 2005; 5:12. PMC: 1142306. DOI: 10.1186/1472-6750-5-12. View

13.

Lee K, Lee J, Kim S, Cho M, Lee J . Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus. Appl Microbiol Biotechnol. 2014; 98(22):9447-57. DOI: 10.1007/s00253-014-5903-4. View

14.

Woguem V, Fogang H, Maggi F, Tapondjou L, Womeni H, Quassinti L . Volatile oil from striped African pepper (Xylopia parviflora, Annonaceae) possesses notable chemopreventive, anti-inflammatory and antimicrobial potential. Food Chem. 2013; 149:183-9. DOI: 10.1016/j.foodchem.2013.10.093. View

15.

Miresmailli S, Isman M . Botanical insecticides inspired by plant-herbivore chemical interactions. Trends Plant Sci. 2013; 19(1):29-35. DOI: 10.1016/j.tplants.2013.10.002. View

16.

Mosmann T . Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983; 65(1-2):55-63. DOI: 10.1016/0022-1759(83)90303-4. View

17.

Petrelli R, Ranjbarian F, DallAcqua S, Papa F, Iannarelli R, Ngahang Kamte S . An overlooked horticultural crop, Smyrnium olusatrum, as a potential source of compounds effective against African trypanosomiasis. Parasitol Int. 2017; 66(2):146-151. DOI: 10.1016/j.parint.2017.01.001. View

18.

Graziose R, Rathinasabapathy T, Lategan C, Poulev A, Smith P, Grace M . Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L. J Ethnopharmacol. 2010; 133(1):26-30. PMC: 3010440. DOI: 10.1016/j.jep.2010.08.059. View

19.

Kang Z, Liu F, Zhang Z, Tian H, Liu T . Volatile β-Ocimene Can Regulate Developmental Performance of Peach Aphid Through Activation of Defense Responses in Chinese Cabbage . Front Plant Sci. 2018; 9:708. PMC: 5985497. DOI: 10.3389/fpls.2018.00708. View

20.

Isman M . Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world. Annu Rev Entomol. 2005; 51:45-66. DOI: 10.1146/annurev.ento.51.110104.151146. View