Expression of THSD7A in Neoplasm Tissues and Its Relationship with Proteinuria

Overview

Journal BMC Nephrol

Publisher Biomed Central

Specialty Nephrology

Date 2019 Aug 25

PMID 31443644

Citations 15

Authors

Li Xian

Dandan Dong

Jiamei Luo

Ling Zhuo

Ke Li

Ping Zhang

Wei Wang

Ying Xu

Gang Xu

Li Wang

Guisen Li

Affiliations

Soon will be listed here.

Abstract

Background: Thrombospondin type 1 domain containing 7A (THSD7A) was recently identified target autoantigen in membranous nephropathy (MN). However, patients with positive THSD7A expression were prone to have malignancies. THSD7A was found to be expressed in a variety of malignant tumors. In this study, we investigated the histologic expression of THSD7A in colorectal or breast cancers, as well as the relationship between THSD7A expression and proteinuria in the patients with cancers.

Method: A total of 101 patients were enrolled in the study, 81 of them had colorectal cancer and 20 had breast cancer. THSD7A expression was detected by immunohistochemical staining in tumor tissues. The clinical and laboratory parameters of these patients before their tumor resection were collected.

Results: Positive expression rates of THSD7A in the two types of tumor tissues were very high, 97.5% in colorectal cancer, and 100% in breast cancer. THSD7A expression was also detected in lymph nodes of two patients with lymph node metastasis. Total 11 patients (10.9%) had proteinuria before surgery. Among the 4 patients who had proteinuria and were followed up, the proteinuria of 3 patients disappeared after surgery.

Conclusions: The positive rate of THSD7A expression was very high in human colorectal cancer or breast cancer. It might be an important link between malignant tumors and kidney diseases.

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References

Carmeliet P, Jain R . Angiogenesis in cancer and other diseases. Nature. 2000; 407(6801):249-57. DOI: 10.1038/35025220. View

Debiec H, Guigonis V, Mougenot B, Decobert F, Haymann J, Bensman A . Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies. N Engl J Med. 2002; 346(26):2053-60. DOI: 10.1056/NEJMoa012895. View

HEYMANN W, Wilson S . Hyperlipemia in early stages of acute glomerular nephritis. J Clin Invest. 1959; 38(1, Part 1):186-92. PMC: 444124. DOI: 10.1172/JCI103787. View

Beck Jr L, Bonegio R, Lambeau G, Beck D, Powell D, Cummins T . M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med. 2009; 361(1):11-21. PMC: 2762083. DOI: 10.1056/NEJMoa0810457. View

Beck Jr L, Salant D . Membranous nephropathy: recent travels and new roads ahead. Kidney Int. 2010; 77(9):765-70. DOI: 10.1038/ki.2010.34. View

Beck Jr L . Membranous nephropathy and malignancy. Semin Nephrol. 2010; 30(6):635-44. DOI: 10.1016/j.semnephrol.2010.09.011. View

Debiec H, Ronco P . PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy. N Engl J Med. 2011; 364(7):689-90. DOI: 10.1056/NEJMc1011678. View

Wang C, Chen I, Kuo M, Su P, Lai Z, Wang C . Zebrafish Thsd7a is a neural protein required for angiogenic patterning during development. Dev Dyn. 2011; 240(6):1412-21. DOI: 10.1002/dvdy.22641. View

Kuo M, Wang C, Wu H, Chang S, Chuang Y . Soluble THSD7A is an N-glycoprotein that promotes endothelial cell migration and tube formation in angiogenesis. PLoS One. 2011; 6(12):e29000. PMC: 3237571. DOI: 10.1371/journal.pone.0029000. View

10.

Yano Y, Fujimoto S, Asahi K, Watanabe T . Prevalence of chronic kidney disease in China. Lancet. 2012; 380(9838):213-4. DOI: 10.1016/S0140-6736(12)61209-4. View

11.

Tomas N, Beck Jr L, Meyer-Schwesinger C, Seitz-Polski B, Ma H, Zahner G . Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. N Engl J Med. 2014; 371(24):2277-2287. PMC: 4278759. DOI: 10.1056/NEJMoa1409354. View

12.

Iwakura T, Ohashi N, Kato A, Baba S, Yasuda H . Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy. PLoS One. 2015; 10(9):e0138841. PMC: 4578926. DOI: 10.1371/journal.pone.0138841. View

13.

Larsen C, Cossey L, Beck L . THSD7A staining of membranous glomerulopathy in clinical practice reveals cases with dual autoantibody positivity. Mod Pathol. 2016; 29(4):421-6. PMC: 4820679. DOI: 10.1038/modpathol.2016.32. View

14.

Hoxha E, Wiech T, Stahl P, Zahner G, Tomas N, Meyer-Schwesinger C . A Mechanism for Cancer-Associated Membranous Nephropathy. N Engl J Med. 2016; 374(20):1995-6. DOI: 10.1056/NEJMc1511702. View

15.

Tomas N, Hoxha E, Reinicke A, Fester L, Helmchen U, Gerth J . Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. J Clin Invest. 2016; 126(7):2519-32. PMC: 4922694. DOI: 10.1172/JCI85265. View

16.

Hoxha E, Beck Jr L, Wiech T, Tomas N, Probst C, Mindorf S . An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy. J Am Soc Nephrol. 2016; 28(2):520-531. PMC: 5280014. DOI: 10.1681/ASN.2016010050. View

17.

Stahl P, Hoxha E, Wiech T, Schroder C, Simon R, Stahl R . THSD7A expression in human cancer. Genes Chromosomes Cancer. 2016; 56(4):314-327. DOI: 10.1002/gcc.22440. View

18.

Beck Jr L . PLA2R and THSD7A: Disparate Paths to the Same Disease?. J Am Soc Nephrol. 2017; 28(9):2579-2589. PMC: 5576947. DOI: 10.1681/ASN.2017020178. View

19.

Wang J, Cui Z, Lu J, Probst C, Zhang Y, Wang X . Circulating Antibodies against Thrombospondin Type-I Domain-Containing 7A in Chinese Patients with Idiopathic Membranous Nephropathy. Clin J Am Soc Nephrol. 2017; 12(10):1642-1651. PMC: 5628706. DOI: 10.2215/CJN.01460217. View

20.

Hou Z, Abudureheman A, Wang L, Hasim A, Ainiwaer J, Zhang H . Expression, prognosis and functional role of Thsd7a in esophageal squamous cell carcinoma of Kazakh patients, Xinjiang. Oncotarget. 2017; 8(36):60539-60557. PMC: 5601160. DOI: 10.18632/oncotarget.16966. View