Evaluation of Antiamnesic Activity of Essential Oil on Scopolamine-induced Amnesia in Rats: and Approaches

Overview

Journal Heliyon

Specialty Social Sciences

Date 2019 Aug 24

PMID 31440590

Citations 4

Authors

Eyup Bagci

Emel Akbaba

Calin Maniu

Eugen Ungureanu

Lucian Hritcu

Affiliations

Soon will be listed here.

Abstract

Plants of genus have been used in folk medicine for wound healing, in the alleviation of stomach, liver, and rheumatism pains, as antioxidant, cognitive-enhancer, sedative and antiseptic, stimulant and tonic agents. The present study aimed to evaluate whether essential oil (1% and 3%) administered for 21 days attenuates cognitive deficits and exhibits anxiolytic and antidepressant-profile in the scopolamine-induced amnesia in rats. Rats were randomly divided into six groups (n = 6): (1) control, (2) scopolamine (Sco, 0.7 mg/kg) (3, 4) essential oil treatment groups (SEO, 1% and 3%), (5) diazepam (DIAZ, 1.5 mg/kg) and (6) tramadol (TRM, 10 mg/kg). To establish an animal model of amnesia, Sco (0.7 mg/kg), a muscarinic acetylcholine receptor antagonist, was injected into male Wistar rats. Y-maze (memory), radial arm-maze (memory), elevated plus-maze (anxiety), and forced swimming (depression) tests were employed. Molecular interactions of chemical compounds from the essential oil with the GABA receptor was explored via molecular docking experiments. Using behavioral tests, we demonstrated that inhalation of essential oil exerts significant antiamnesic activity as well as anxiolytic-antidepressant-like effects in the Sco-treated rats. Our data revealed that oil could act as a promising phytopharmaceutical agent for improving dementia-related abnormalities.

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