Serum TSLP is a Potential Biomarker of Psoriasis Vulgaris Activity

Overview

Journal Psoriasis (Auckl)

Publisher Dove Medical Press

Date 2019 Aug 24

PMID 31440462

Citations 13

Authors

Mohamed Ibrahim El-Ghareeb

Afaf Helmy

Sally Al Kazzaz

Hanan Samir

Affiliations

Soon will be listed here.

Abstract

Background: The proallergic cytokine, thymic stromal lymphopoietin (TSLP) may synergize with T cell-derived CD40 ligand (CD40L) to allow IL-23 production in patients with psoriasis. IL-23 is a central cytokine that mediates the inappropriate immune reaction in patients with psoriasis.

Objective: The aim of the study was to correlate serum level of TSLP with psoriasis severity.

Methods: The study was carried out on 53 patients with psoriasis. They were divided into mild, moderate, and severe according to PASI score. The patients' ages ranged from 10 to 62 years. The patients included 29 males and 24 females. A total of 53 healthy subjects with matched age and sex served as control group. Blood samples were collected from the venous blood of the patients and control subjects then the serum was separated. The serum samples were immediately frozen at -20°C. Serum TSLP was measured by Sandwich Enzyme-linked Immunosorbant Assay (ELISA).

Results: There was a statistically very highly significant increase (<0.001) in serum TSLP levels among the case group (1042.7±812.93) compared to the control group (314.21±220.78). There was also a statistically very highly significant increase (<0.001) in serum TSLP levels with increased psoriasis severity estimated by PASI score.

Conclusion: In this study, we found that serum TSLP is elevated in psoriasis patients and is correlated with disease severity.

Citing Articles

A Comparative Study on Serum Levels of "Thymic Stromal Lymphopoietin" Between Patients with Psoriasis Vulgaris and Healthy Individuals: A Case-Control Study.

Kollabathula S, Venkatachalam K, Divya K, Guruprasad P, Nayar P Indian Dermatol Online J. 2024; 15(3):449-453.

PMID: 38845675 PMC: 11152502. DOI: 10.4103/idoj.idoj_742_23.

Thymic Stromal Lymphopoietin Activates Mouse Dendritic Cells Through the JAK/SYK Pathway in Promoting Th17 Response in Psoriasis.

Song C, Sun J, Zhao Z, Zhang X, Ding X, Liang X Balkan Med J. 2024; 41(3):174-185.

PMID: 38700313 PMC: 11077931. DOI: 10.4274/balkanmedj.galenos.2024.2024-1-96.

The Role of Alarmins in the Pathogenesis of Rheumatoid Arthritis, Osteoarthritis, and Psoriasis.

Kielbowski K, Stanska W, Bakinowska E, Rusinski M, Pawlik A Curr Issues Mol Biol. 2024; 46(4):3640-3675.

PMID: 38666958 PMC: 11049642. DOI: 10.3390/cimb46040228.

Circulating Immune Landscape Profiling in Psoriasis Vulgaris and Psoriatic Arthritis by Mass Cytometry.

Sang X, Gan T, Ge G, Li D, Mei Y, Pan C J Immunol Res. 2024; 2024:9927964.

PMID: 38590608 PMC: 11001477. DOI: 10.1155/2024/9927964.

Bombesin receptor-activated protein homolog deficiency altered the pattern of pathological changes of psoriasis - like skin lesion in mice.

Zheng J, Wang H, Wang J, Peng Z, Yao X, Weber H Int J Med Sci. 2024; 21(2):357-368.

PMID: 38169666 PMC: 10758153. DOI: 10.7150/ijms.89492.

References

Soumelis V, Liu Y . Human thymic stromal lymphopoietin: a novel epithelial cell-derived cytokine and a potential key player in the induction of allergic inflammation. Springer Semin Immunopathol. 2004; 25(3-4):325-33. DOI: 10.1007/s00281-003-0152-0. View

Bowcock A, Krueger J . Getting under the skin: the immunogenetics of psoriasis. Nat Rev Immunol. 2005; 5(9):699-711. DOI: 10.1038/nri1689. View

Zhou B, Comeau M, De Smedt T, Liggitt H, Dahl M, Lewis D . Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol. 2005; 6(10):1047-53. DOI: 10.1038/ni1247. View

Zheng Y, Danilenko D, Valdez P, Kasman I, Eastham-Anderson J, Wu J . Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature. 2006; 445(7128):648-51. DOI: 10.1038/nature05505. View

Cargill M, Schrodi S, Chang M, Garcia V, Brandon R, Callis K . A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 2007; 80(2):273-90. PMC: 1785338. DOI: 10.1086/511051. View

Volpe E, Servant N, Zollinger R, Bogiatzi S, Hupe P, Barillot E . A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol. 2008; 9(6):650-7. DOI: 10.1038/ni.1613. View

Taylor B, Zaph C, Troy A, Du Y, Guild K, Comeau M . TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J Exp Med. 2009; 206(3):655-67. PMC: 2699121. DOI: 10.1084/jem.20081499. View

Costa de Faria J, Aarao A, Jimenez L, Silva O, Regazzi Avelleira J . Inter-rater concordance study of the PASI (Psoriasis Area and Severity Index). An Bras Dermatol. 2010; 85(5):625-9. DOI: 10.1590/s0365-05962010000500005. View

Johnson M, Armstrong A . Clinical and histologic diagnostic guidelines for psoriasis: a critical review. Clin Rev Allergy Immunol. 2012; 44(2):166-72. DOI: 10.1007/s12016-012-8305-3. View

10.

Sato-Deguchi E, Imafuku S, Chou B, Ishii K, Hiromatsu K, Nakayama J . Topical vitamin D₃ analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions. Br J Dermatol. 2012; 167(1):77-84. DOI: 10.1111/j.1365-2133.2012.10917.x. View

11.

Eckhart L, Fischer H, Tschachler E . Mechanisms and emerging functions of DNA degradation in the epidermis. Front Biosci (Landmark Ed). 2012; 17(7):2461-75. DOI: 10.2741/4065. View

12.

Mudigonda P, Mudigonda T, Feneran A, Alamdari H, Sandoval L, Feldman S . Interleukin-23 and interleukin-17: importance in pathogenesis and therapy of psoriasis. Dermatol Online J. 2012; 18(10):1. View

13.

Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu M, Bogiatzi S . Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis. J Allergy Clin Immunol. 2014; 134(2):373-81. DOI: 10.1016/j.jaci.2014.04.022. View

14.

Tsilingiri K, Fornasa G, Rescigno M . Thymic Stromal Lymphopoietin: To Cut a Long Story Short. Cell Mol Gastroenterol Hepatol. 2017; 3(2):174-182. PMC: 5331833. DOI: 10.1016/j.jcmgh.2017.01.005. View