The Sweet-Side of Leukocytes: Galectins As Master Regulators of Neutrophil Function

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2019 Aug 24

PMID 31440233

Citations 33

Authors

Brian S Robinson

Connie M Arthur

Birk Evavold

Ethan Roback

Nourine A Kamili

Caleb S Stowell

Mary L Vallecillo-Zuniga

Pam M Van Ry

Marcelo Dias-Baruffi

Richard D Cummings

Sean R Stowell

Affiliations

Soon will be listed here.

Abstract

Among responders to microbial invasion, neutrophils represent one of the earliest and perhaps most important factors that contribute to initial host defense. Effective neutrophil immunity requires their rapid mobilization to the site of infection, which requires efficient extravasation, activation, chemotaxis, phagocytosis, and eventual killing of potential microbial pathogens. Following pathogen elimination, neutrophils must be eliminated to prevent additional host injury and subsequent exacerbation of the inflammatory response. Galectins, expressed in nearly every tissue and regulated by unique sensitivity to oxidative and proteolytic inactivation, appear to influence nearly every aspect of neutrophil function. In this review, we will examine the impact of galectins on neutrophils, with a particular focus on the unique biochemical traits that allow galectin family members to spatially and temporally regulate neutrophil function.

Citing Articles

Galectins and Liver Diseases.

Mimura S, Morishita A, Oura K, Takuma K, Nakahara M, Tadokoro T Int J Mol Sci. 2025; 26(2).

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Reduced form of Galectin-1 Suppresses Osteoclastic Differentiation of Human Peripheral Blood Mononuclear Cells and Murine RAW264 Cells In Vitro.

Takeuchi T, Oyama M, Tamura M, Arata Y, Hatanaka T Biomolecules. 2024; 14(1).

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Galectin-1 in Pancreatic Ductal Adenocarcinoma: Bridging Tumor Biology, Immune Evasion, and Therapeutic Opportunities.

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