Restrictive Measure for the Commercialization of Antimicrobials in Brazil: Results Achieved

Overview

Journal Rev Saude Publica

Specialty Public Health

Date 2019 Aug 22

PMID 31432930

Authors

Josiane Moreira da Costa

Cristiano Soares de Moura

Cristiane Aparecida Menezes de Padua

Aline Siqueira Fogal Vegi

Sergia Maria Starling Magalhaes

Marina Barra Rodrigues

Andreia Queiroz Ribeiro

Affiliations

Soon will be listed here.

Abstract

Objective: To assess whether the incidence of hospital infection by a resistant microorganism decreased after the implementation of the restrictive measure of the National Health Surveillance Agency for the commercialization of antimicrobials.

Methods: A historical cohort study of medical records of adult patients admitted to a general and public hospital from May 2010 to July 2011. A cohort was formed with patients admitted in the period before the restrictive measure for the commercialization of antimicrobials (Phase I) and a second cohort was formed with patients admitted after the implementation of the restrictive measure (Phase II).

Results: The instantaneous risk of hospital infection by a resistant microorganism was estimated at seven by 1,000 people-time (95%CI 0.006-0.008) in Phase I, and four by 1,000 people-time (95%CI 0.003-0.005) in Phase II of the study. The differences between the survival curves in the different phases of the study and stratified by age group were also significant (p < 0.05).

Conclusions: The results suggest that the implementation of the restrictive measure of the commercialization of antimicrobials by the National Health Surveillance Agency reduced the incidence of hospital infection by a resistant microorganism.

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