G Protein-coupled Receptor Kinase 2 (GRK2) As a Multifunctional Signaling Hub

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2019 Aug 22

PMID 31432234

Citations 43

Authors

Petronila Penela

Catalina Ribas

Francisco Sanchez-Madrid

Federico Mayor Jr

Affiliations

Soon will be listed here.

Abstract

Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled receptor (GPCR) signaling and also via phosphorylation or scaffolding interactions with an extensive number of non-GPCR cellular partners. GRK2 multifunctionality arises from its multidomain structure and from complex mechanisms of regulation of its expression levels, activity, and localization within the cell, what allows the precise spatio-temporal shaping of GRK2 targets. A better understanding of the GRK2 interactome and its modulation mechanisms is helping to identify the GRK2-interacting proteins and its substrates involved in the participation of this kinase in different cellular processes and pathophysiological contexts.

Citing Articles

GRK2 and Mitochondrial Dynamics in Cardiovascular Health and Disease.

Gatto C, Rusciano M, Visco V, Ciccarelli M Int J Mol Sci. 2025; 26(5).

PMID: 40076919 PMC: 11900936. DOI: 10.3390/ijms26052299.

Canonical or non-canonical, all aspects of G protein-coupled receptor kinase 2 in heart failure.

Kaplan A, El-Samadi L, Zahreddine R, Amin G, Booz G, Zouein F Acta Physiol (Oxf). 2025; 241(3):e70010.

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Global Research Trends and Focus on the Link Between Heart Failure and NLRP3 Inflammasome: A Bibliometric Analysis From 2010 to 2024.

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Novel role of GRK2 in isoprenaline-induced activation of Na/H exchanger 3 independent of β2-adrenergic receptor signaling.

Dai Y, Wen H, Lai X, Huang J, Li J Mol Biol Rep. 2025; 52(1):218.

PMID: 39932653 DOI: 10.1007/s11033-025-10326-4.

The roles of G protein-coupled receptor kinase 2 in renal diseases.

Du J, Wu X, Ni L J Cell Mol Med. 2024; 28(20):e70154.

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