Increase of the Serum FGF-23 in Ossification of the Posterior Longitudinal Ligament

Overview

Journal Global Spine J

Publisher Sage Publications

Date 2019 Aug 22

PMID 31431871

Citations 14

Authors

Yoshiharu Kawaguchi

Isao Kitajima

Masato Nakano

Taketoshi Yasuda

Shoji Seki

Kayo Suzuki

Yasuhito Yahara

Hiroto Makino

Yasuhiro Ujihara

Tomohiro Ueno

Tomoatsu Kimura

Affiliations

Soon will be listed here.

Abstract

Study Design: Case-control study.

Objectives: To determine the possible pathogenesis of ossification of the posterior longitudinal ligament (OPLL) in regard to the serum concentration of fibroblast growth factor 23 (FGF-23).

Methods: The study included 95 patients with OPLL and a control group of 73 age- and sex-matched volunteers. The serum concentrations of FGF-23, creatinine (Cre), alkaline phosphatase, calcium (Ca), inorganic phosphate (Pi), and hypersensitive C-reactive protein (hs-CRP) were analyzed from blood samples, and Cre, Ca, Pi, and tubular reabsorption of phosphate were measured using urine samples. We evaluated the severity of ossified spinal lesions in patients with OPLL according to the ossification index (the OP index and the OS index). Data was compared between the OPLL and control group and between the OPLL progression and no progression group.

Results: Serum FGF-23 and hs-CRP were higher, and serum Pi was lower in patients with OPLL than in the controls. There was a positive correlation between FGF-23 and hs-CRP and a negative correlation between serum Pi and the OS index; however, the correlations were very weak. Overall, 31.7% of patients had progression of OPLL during follow-up. FGF-23 and hs-CRP were higher in the progression group than in the no progression group.

Conclusions: These results might indicate that FGF-23 and hs-CRP are positive markers for OPLL. Phosphate metabolism via FGF-23 might be a target for future study on the pathogenesis of OPLL.

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