Specific and Ubiquitous Expression of Different Zn Finger Protein Genes in the Mouse

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1988 Nov 11

PMID 3143103

Citations 10

Authors

K Chowdhury

H Rohdewohld

P Gruss

Affiliations

Soon will be listed here.

Abstract

Zinc finger proteins (Zfp) are members of a multigene family encoding Zn mediated nucleic acid binding proteins. They have been isolated from various organisms including yeast, Drosophila, Xenopus mouse and human. All Zfp share the 28-30 amino acid long finger repeats containing conserved residues at specific positions. Some of these proteins have been identified as transcriptional regulatory factors. In this paper, we describe the isolation, DNA sequence determination and the expression pattern in developing embryos and adult tissues of 3 new members of the mouse Zfp. All of them are expressed as multiple transcripts. Unaltered level of mkr5 expression could be detected in 10-15 day whole embryo RNAs but its level started to decrease from day 16. In the adult animal, predominant expression was detected only in the ovary. In contrast, mkr3 and 4 were expressed at a constant level in all embryos and tissues tested. These data suggest the presence of both tissue specific and ubiquitious Zfp in the mouse.

Citing Articles

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Identification of an immediate-early gene in the Marek's disease virus long internal repeat region which encodes a unique 14-kilodalton polypeptide.

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Zfp-51, a murine zinc finger encoding gene mapping to the t-complex region of chromosome 17, encodes 19 contiguous zinc fingers and is ubiquitously expressed.

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Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene.

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Mouse genes coding for "zinc-finger"-containing proteins: characterization and expression in differentiated cells.

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References

Maxam A, Gilbert W . A new method for sequencing DNA. Proc Natl Acad Sci U S A. 1977; 74(2):560-4. PMC: 392330. DOI: 10.1073/pnas.74.2.560. View

Colberg-Poley A, Voss S, Gruss P . Homoeo box genes of the mouse. Oxf Surv Eukaryot Genes. 1987; 4:92-115. View

Nusslein-Volhard C, Wieschaus E . Mutations affecting segment number and polarity in Drosophila. Nature. 1980; 287(5785):795-801. DOI: 10.1038/287795a0. View

Hanas J, Hazuda D, Bogenhagen D, Wu F, Wu C . Xenopus transcription factor A requires zinc for binding to the 5 S RNA gene. J Biol Chem. 1983; 258(23):14120-5. View

Ginsberg A, King B, Roeder R . Xenopus 5S gene transcription factor, TFIIIA: characterization of a cDNA clone and measurement of RNA levels throughout development. Cell. 1984; 39(3 Pt 2):479-89. DOI: 10.1016/0092-8674(84)90455-0. View

Kalderon D, Roberts B, Richardson W, Smith A . A short amino acid sequence able to specify nuclear location. Cell. 1984; 39(3 Pt 2):499-509. DOI: 10.1016/0092-8674(84)90457-4. View

Brown R, Sander C, Argos P . The primary structure of transcription factor TFIIIA has 12 consecutive repeats. FEBS Lett. 1985; 186(2):271-4. DOI: 10.1016/0014-5793(85)80723-7. View

Miller J, McLachlan A, Klug A . Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J. 1985; 4(6):1609-14. PMC: 554390. DOI: 10.1002/j.1460-2075.1985.tb03825.x. View

Vincent A, Colot H, Rosbash M . Sequence and structure of the serendipity locus of Drosophila melanogaster. A densely transcribed region including a blastoderm-specific gene. J Mol Biol. 1985; 186(1):149-66. DOI: 10.1016/0022-2836(85)90265-7. View

10.

Desplan C, Theis J, Ofarrell P . The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity. Nature. 1985; 318(6047):630-5. PMC: 2880619. DOI: 10.1038/318630a0. View

11.

Hartshorne T, BLUMBERG H, Young E . Sequence homology of the yeast regulatory protein ADR1 with Xenopus transcription factor TFIIIA. Nature. 1986; 320(6059):283-7. DOI: 10.1038/320283a0. View

12.

Berg J . Potential metal-binding domains in nucleic acid binding proteins. Science. 1986; 232(4749):485-7. DOI: 10.1126/science.2421409. View

13.

Shaw G, Kamen R . A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell. 1986; 46(5):659-67. DOI: 10.1016/0092-8674(86)90341-7. View

14.

Schuh R, Aicher W, Gaul U, Cote S, Preiss A, Maier D . A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene. Cell. 1986; 47(6):1025-32. DOI: 10.1016/0092-8674(86)90817-2. View

15.

Diakun G, Fairall L, Klug A . EXAFS study of the zinc-binding sites in the protein transcription factor IIIA. Nature. 1986; 324(6098):698-9. DOI: 10.1038/324698a0. View

16.

Gehring W, Hiromi Y . Homeotic genes and the homeobox. Annu Rev Genet. 1986; 20:147-73. DOI: 10.1146/annurev.ge.20.120186.001051. View

17.

Chowdhury K, Deutsch U, Gruss P . A multigene family encoding several "finger" structures is present and differentially active in mammalian genomes. Cell. 1987; 48(5):771-8. DOI: 10.1016/0092-8674(87)90074-2. View

18.

Frankel A, Berg J, Pabo C . Metal-dependent folding of a single zinc finger from transcription factor IIIA. Proc Natl Acad Sci U S A. 1987; 84(14):4841-5. PMC: 305201. DOI: 10.1073/pnas.84.14.4841. View

19.

BLUMBERG H, Eisen A, Sledziewski A, Bader D, Young E . Two zinc fingers of a yeast regulatory protein shown by genetic evidence to be essential for its function. Nature. 1987; 328(6129):443-5. DOI: 10.1038/328443a0. View

20.

Ollo R, Maniatis T . Drosophila Krüppel gene product produced in a baculovirus expression system is a nuclear phosphoprotein that binds to DNA. Proc Natl Acad Sci U S A. 1987; 84(16):5700-4. PMC: 298930. DOI: 10.1073/pnas.84.16.5700. View