Mammalian Pathogenicity and Transmissibility of a Reassortant Eurasian Avian-like A(H1N1v) Influenza Virus Associated with Human Infection in China (2015)

Overview

Journal Virology

Specialty Microbiology

Date 2019 Aug 21

PMID 31430632

Citations 8

Authors

Joanna A Pulit-Penaloza

Jessica A Belser

Terrence M Tumpey

Taronna R Maines

Affiliations

Soon will be listed here.

Abstract

Swine-origin (variant) H1 influenza A viruses associated with numerous human infections in North America in recent years have been extensively studied in vitro and in mammalian models to determine their pandemic potential. However, limited information is available on Eurasian avian-like lineage variant H1 influenza viruses. In 2015, A/Hunan/42443/2015 virus was isolated from a child in China with a severe infection. Molecular analysis revealed that this virus possessed several key virulence and human adaptation markers. Similar to what was previously observed in C57BL/6J mice, we report here that in the BALB/c mouse model, A/Hunan/42443/2015 virus caused more severe morbidity and higher mortality than did North American variant H1 virus isolates. Furthermore, the virus efficiently replicated throughout the respiratory tract of ferrets and exhibited a capacity for transmission in this model, underscoring the need to monitor zoonotic viruses that cross the species barrier as they continue to pose a pandemic threat.

Citing Articles

Emergence of Eurasian Avian-Like Swine Influenza A (H1N1) virus in a child in Shandong Province, China.

He Y, Song S, Wu J, Wu J, Zhang L, Sun L BMC Infect Dis. 2024; 24(1):550.

PMID: 38824508 PMC: 11143696. DOI: 10.1186/s12879-024-09441-7.

The evolution, pathogenicity and transmissibility of quadruple reassortant H1N2 swine influenza virus in China: A potential threat to public health.

Cui X, Ma J, Pang Z, Chi L, Mai C, Liu H Virol Sin. 2024; 39(2):205-217.

PMID: 38346538 PMC: 11074646. DOI: 10.1016/j.virs.2024.02.002.

Interspecies Transmission of Swine Influenza A Viruses and Human Seasonal Vaccine-Mediated Protection Investigated in Ferret Model.

van Diemen P, Byrne A, Ramsay A, Watson S, Nunez A, V Moreno A Emerg Infect Dis. 2023; 29(9):1798-1807.

PMID: 37610158 PMC: 10461666. DOI: 10.3201/eid2909.230066.

Utility of Human Data in Risk Assessments of Influenza A Virus Using the Ferret Model.

Creager H, Kieran T, Zeng H, Sun X, Pulit-Penaloza J, Holmes K J Virol. 2023; 97(1):e0153622.

PMID: 36602361 PMC: 9888249. DOI: 10.1128/jvi.01536-22.

Genetic characterization and pathogenicity of a Eurasian avian-like H1N1 swine influenza reassortant virus.

Zhu H, Li X, Chen H, Qian P Virol J. 2022; 19(1):205.

PMID: 36461007 PMC: 9716174. DOI: 10.1186/s12985-022-01936-6.

References

Szretter K, Balish A, Katz J . Influenza: propagation, quantification, and storage. Curr Protoc Microbiol. 2008; Chapter 15:Unit 15G.1. DOI: 10.1002/0471729256.mc15g01s3. View

Myers K, Olsen C, Gray G . Cases of swine influenza in humans: a review of the literature. Clin Infect Dis. 2007; 44(8):1084-8. PMC: 1973337. DOI: 10.1086/512813. View

Bussey K, Bousse T, Desmet E, Kim B, Takimoto T . PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. J Virol. 2010; 84(9):4395-406. PMC: 2863787. DOI: 10.1128/JVI.02642-09. View

Smith G, Bahl J, Vijaykrishna D, Zhang J, Poon L, Chen H . Dating the emergence of pandemic influenza viruses. Proc Natl Acad Sci U S A. 2009; 106(28):11709-12. PMC: 2709671. DOI: 10.1073/pnas.0904991106. View

Mehle A, Doudna J . Adaptive strategies of the influenza virus polymerase for replication in humans. Proc Natl Acad Sci U S A. 2009; 106(50):21312-6. PMC: 2789757. DOI: 10.1073/pnas.0911915106. View

Pulit-Penaloza J, Simpson N, Yang H, Creager H, Jones J, Carney P . Assessment of Molecular, Antigenic, and Pathological Features of Canine Influenza A(H3N2) Viruses That Emerged in the United States. J Infect Dis. 2017; 216(suppl_4):S499-S507. PMC: 5735346. DOI: 10.1093/infdis/jiw620. View

Belser J, Wadford D, Pappas C, Gustin K, Maines T, Pearce M . Pathogenesis of pandemic influenza A (H1N1) and triple-reassortant swine influenza A (H1) viruses in mice. J Virol. 2010; 84(9):4194-203. PMC: 2863721. DOI: 10.1128/JVI.02742-09. View

Qiao C, Liu L, Yang H, Chen Y, Xu H, Chen H . Novel triple reassortant H1N2 influenza viruses bearing six internal genes of the pandemic 2009/H1N1 influenza virus were detected in pigs in China. J Clin Virol. 2014; 61(4):529-34. DOI: 10.1016/j.jcv.2014.10.014. View

Wang D, Qi S, Li X, Guo J, Tan M, Han G . Human infection with Eurasian avian-like influenza A(H1N1) virus, China. Emerg Infect Dis. 2013; 19(10):1709-11. PMC: 3810748. DOI: 10.3201/eid1910.130420. View

10.

Lewis N, Russell C, Langat P, Anderson T, Berger K, Bielejec F . The global antigenic diversity of swine influenza A viruses. Elife. 2016; 5:e12217. PMC: 4846380. DOI: 10.7554/eLife.12217. View

11.

Liu Q, Qiao C, Marjuki H, Bawa B, Ma J, Guillossou S . Combination of PB2 271A and SR polymorphism at positions 590/591 is critical for viral replication and virulence of swine influenza virus in cultured cells and in vivo. J Virol. 2011; 86(2):1233-7. PMC: 3255826. DOI: 10.1128/JVI.05699-11. View

12.

de Jong J, PACCAUD M, Huffels N, Verwei C, Weijers T, BANGMA P . Isolation of swine-like influenza A(H1N1) viruses from man in Switzerland and The Netherlands. Ann Inst Pasteur Virol. 1988; 139(4):429-37. DOI: 10.1016/s0769-2617(88)80078-9. View

13.

Barman S, Krylov P, Fabrizio T, Franks J, Turner J, Seiler P . Pathogenicity and transmissibility of North American triple reassortant swine influenza A viruses in ferrets. PLoS Pathog. 2012; 8(7):e1002791. PMC: 3400563. DOI: 10.1371/journal.ppat.1002791. View

14.

Pulit-Penaloza J, Sun X, Creager H, Zeng H, Belser J, Maines T . Pathogenesis and Transmission of Novel Highly Pathogenic Avian Influenza H5N2 and H5N8 Viruses in Ferrets and Mice. J Virol. 2015; 89(20):10286-93. PMC: 4580194. DOI: 10.1128/JVI.01438-15. View

15.

Pascua P, Song M, Lee J, Baek Y, Kwon H, Park S . Virulence and transmissibility of H1N2 influenza virus in ferrets imply the continuing threat of triple-reassortant swine viruses. Proc Natl Acad Sci U S A. 2012; 109(39):15900-5. PMC: 3465388. DOI: 10.1073/pnas.1205576109. View

16.

Pulit-Penaloza J, Belser J, Tumpey T, Maines T . Sowing the Seeds of a Pandemic? Mammalian Pathogenicity and Transmissibility of H1 Variant Influenza Viruses from the Swine Reservoir. Trop Med Infect Dis. 2019; 4(1). PMC: 6473686. DOI: 10.3390/tropicalmed4010041. View

17.

Shinde V, Bridges C, Uyeki T, Shu B, Balish A, Xu X . Triple-reassortant swine influenza A (H1) in humans in the United States, 2005-2009. N Engl J Med. 2009; 360(25):2616-25. DOI: 10.1056/NEJMoa0903812. View

18.

Steel J, Lowen A, Mubareka S, Palese P . Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N. PLoS Pathog. 2009; 5(1):e1000252. PMC: 2603332. DOI: 10.1371/journal.ppat.1000252. View

19.

Pulit-Penaloza J, Jones J, Sun X, Jang Y, Thor S, Belser J . Antigenically Diverse Swine Origin H1N1 Variant Influenza Viruses Exhibit Differential Ferret Pathogenesis and Transmission Phenotypes. J Virol. 2018; 92(11). PMC: 5952129. DOI: 10.1128/JVI.00095-18. View

20.

Sellers R, Clifford C, Treuting P, Brayton C . Immunological variation between inbred laboratory mouse strains: points to consider in phenotyping genetically immunomodified mice. Vet Pathol. 2011; 49(1):32-43. DOI: 10.1177/0300985811429314. View