Long-term Vs. Recent-onset Obesity: Their Contribution to Cardiometabolic Risk in Adolescence

Overview

Journal Pediatr Res

Specialties Biology
Pediatrics

Date 2019 Aug 20

PMID 31426054

Citations 4

Authors

Raquel Burrows

Paulina Correa-Burrows

Jose Rogan

Evaline Cheng

Estela Blanco

Sheila Gahagan

Affiliations

Soon will be listed here.

Abstract

Background: The contribution of long-term vs. recent-onset obesity to cardiometabolic risk in adolescence remains controversial. Here, we aimed to investigate the association of time of onset and length of obesity with the cardiometabolic profile of adolescence.

Methods: Prospective study in 678 16-year-olds. BMI was measured at birth-1-5-10-16 years and BMI trajectories were interpolated using cubic splines. BMI > 2 SD at <6 years was defined as early obesity. Waist circumference (WC), blood pressure, lipid and glucose profiles were measured at 16 years. A cardiometabolic risk score was computed (MetS_score). According to the BMI trajectory, four groups were defined: participants who were never obese (NOB), participants with obesity during adolescence (recent-onset obese (ROB)), participants who were obese in early childhood but transitioned to normal/overweight as preadolescents (formerly obese (FOB)), and participants who were obese in early childhood and remained obese (persistently obese (POB)).

Results: ROBs and POBs had significantly unhealthier cardiometabolic profile than NOBs. No differences were observed in the cardiometabolic profile of ROBs compared to POBs. Although FOBs had higher WC and MetS_score than NOBs, no differences were found in other biomarkers. FOBs were in healthier cardiometabolic condition than ROBs and POBs.

Conclusions: Both long-term and recent-onset obesity increase the cardiometabolic risk in adolescents.

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