Nitric Oxide Attenuates the Inflammatory Effects of Air During Extracorporeal Circulation

Overview

Journal ASAIO J

Specialty General Surgery

Date 2019 Aug 20

PMID 31425266

Citations 3

Authors

John M Toomasian

Mark M P Jeakle

Mark W Langley

Clinton J Poling

Gergely Lautner

Orsolya Lautner-Csorba

Mark M Meyerhoff

Ben Jamin D Carr

Alvaro Rojas-Pena

Jonathan W Haft

Robert H Bartlett

Affiliations

Soon will be listed here.

Abstract

Cardiopulmonary bypass causes a systemic inflammatory response reaction that may contribute to postoperative complications. One cause relates to the air/blood interface from the extracorporeal circuit. The modulatory effects of blending nitric oxide (NO) gas into the ventilation/sweep gas of the membrane lung was studied in a porcine model of air-induced inflammation in which NO gas was added and compared with controls with or without an air/blood interface. Healthy swine were supported on partial bypass under four different test conditions. Group 1: no air exposure, group 2: air alone, group 3: air plus 50 ppm NO, and group 4: air plus 500 ppm NO. The NO gas was blended into the ventilation/sweep site of the membrane lung. The platelets and leucocytes were activated by air alone. Addition of NO to the sweep gas attenuated the inflammatory response created by the air/blood interface in this model.

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