Downregulation of Eukaryotic Translation Initiation Factor 3b Inhibited Proliferation and Metastasis of Gastric Cancer

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2019 Aug 20

PMID 31423012

Citations 17

Authors

Fang Ma

Xue Li

Juchao Ren

Ruiting Guo

Yuwei Li

Jichang Liu

Yundong Sun

Zhifang Liu

Jihui Jia

Wenjuan Li

Affiliations

Soon will be listed here.

Abstract

Eukaryotic translation initiation factor 3 (eIF3) plays an important role in the regulation of mRNA translation, cell growth and cancer development. eIF3b is the main scaffolding subunit in the eIF3 complex and has been demonstrated to contribute to the development of several cancers. First, our study found that the downregulation of eIF3b could inhibit the proliferation and metastasis of gastric cancer cells by regulating the expression of cancer-related genes. In addition, the expression of eIF3b correlated with the stage and progression of gastric cancer and was shown to be upregulated in human chronic gastritis and in gastric cancer tissues compared with the expression of eIF3b in normal gastric tissues. Moreover, Helicobacter pylori (H. pylori) infection could upregulate the expression of eIF3b in gastric cancer cells, suggesting that eIF3b might be involved in the carcinogenic process of H. pylori. The above findings identified the oncogenic role of eIF3b in gastric cancer development, and this may contribute to the exploration and discovery of novel therapeutic targets for gastric cancer treatment.

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