Association of Hypoxia-inducible Factor-1α (HIF1α) 1790G/A Gene Polymorphism with Renal Cell Carcinoma and Prostate Cancer Susceptibility: a Meta-analysis

Overview

Journal BMC Med Genet

Publisher Biomed Central

Specialty Genetics

Date 2019 Aug 18

PMID 31419966

Citations 1

Authors

Hong-Yan Li

Tianbiao Zhou

Wenshan Lin

Shujun Lin

Hongzhen Zhong

Affiliations

Soon will be listed here.

Abstract

Background: This meta-analysis was performed to evaluate the relationship between hypoxia-inducible factor-1α (HIF1α) 1790G/A gene polymorphism and the susceptibility to renal cell carcinoma (RCC) and prostate cancer (PCa).

Methods: Association investigations were identified and included from the Embase, Cochrane Library and PubMed databases on March 1, 2018, and eligible investigations were analyzed by meta-analysis. Odds ratios (OR) were used to express the dichotomous data, and the 95% confidence intervals (CI) were also calculated.

Results: In this meta-analysis, we found that the AA genotype of HIF1α 1790G/A was positively associated with the risk of RCC in overall populations, Caucasians, but not for Asians. G allele and GG genotype were not associated with the susceptibility of RCC in overall populations, Caucasians, and Asians. The G allele was negatively associated with PCa susceptibility in overall populations, Asians, but not for Caucasians. GG genotype was negatively associated with PCa susceptibility in Asians, but not for overall populations and Caucasians. HIF1α 1790G/A AA genotype was not associated with PCa susceptibility in overall populations of Caucasians or Asians.

Conclusion: AA genotype of HIF1α 1790G/A was positively associated with RCC risk in overall populations and Caucasians. Furthermore, the G allele was negatively associated with prostate cancer susceptibility in overall populations, Asians, and GG genotype was negatively associated with PCa susceptibility in Asians.

Citing Articles

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